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In this study, we investigated the effects of 2\u2010week mirabegron treatment on the metabolic parameters of mice with a diet\u2010induced obesity (DIO). C57BL\/6JUnib mice were divided into control (CTR) and obese (OB) groups treated with vehicle, and an OB group treated with mirabegron (OB\u00a0+\u00a0MIRA). The obese groups were fed a high\u2010fat diet for 12\u00a0weeks. Mirabegron (10\u00a0mg\/kg\/day) was administrated orally by gavage from weeks 10\u201312. After 2\u00a0weeks of mirabegron treatment, the energy expenditure was assessed with indirect calorimetry. Blood glucose, insulin, glycerol, free fatty acids (FFA), thiobarbituric acid reactive substance (TBAR), and tumour necrosis factor (TNF)\u2010\u03b1 levels were also assessed, and the HOMA index was determined. Liver tissue, brown adipose tissue (BAT), and inguinal white adipose tissue (iWAT) samples were collected for histological examination. The protein expressions of uncoupling protein 1 (UCP1) and mitochondrial transcription factor A (TFAM) were assessed using western blotting of the BAT and iWAT samples. In this study, mirabegron increased the energy expenditure and decreased adiposity in OB\u00a0+\u00a0MIRA. Increased UCP1 expression in BAT without changes in iWAT was also found. Mirabegron decreased circulating levels of FFA, glycerol, insulin, TNF\u2010\u03b1, TBARS and HOMA index. DIO significantly increased the lipid deposits in the liver and BAT, but mirabegron partially reversed this change. Our findings indicate that treatment with mirabegron decreased inflammation and improved metabolism in obese mice. This effect was associated with increased BAT\u2010mediated energy expenditure, but not iWAT beiging, which suggests that mirabegron might be useful for the treatment of obesity and diabetes.<\/jats:p>","DOI":"10.1111\/1440-1681.13566","type":"journal-article","created":{"date-parts":[[2021,8,3]],"date-time":"2021-08-03T14:18:56Z","timestamp":1628000336000},"page":"1477-1487","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["The effects of mirabegron on obesity\u2010induced inflammation and insulin resistance are associated with brown adipose tissue activation but not beiging in the subcutaneous white adipose tissue"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2205-6748","authenticated-orcid":false,"given":"Carmem","family":"Peres Valgas da Silva","sequence":"first","affiliation":[{"name":"Dorothy M. 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