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The aim of our work is to study the consequence of 3\u2010O\u2010Acetyl\u201011\u2010keto\u2010\u03b2\u2010boswellic acid (AKBA) on chronic unpredictable mild stress (CUMS) induced HPA axis dysregulation in relative to glutamate and GABA irregularity in depressive rats. AKBA (5, 10 &amp;15mg\/kg) was administered for 28\u00a0days parallel with CUMS induction in rats. Behavioural studies, tail suspension test (TST), open field exploratory (OFT) and forced swim test (FST) were performed. Biochemical studies including plasma corticosterone, glutamate GABA and glutamic acid decarboxylase (GAD) enzyme activity were studied. Glucocorticoid receptor expression and brain histology were studied to observe the effect of AKBA. CUMS induction results in depressive state of the animals were confirmed by the sucrose preference test. The administration of AKBA significantly reduced the immobility time and improved the exploratory behaviour. Plasma corticosterone and brain glutamate level was decreased and GABA level were increased significantly evident with GAD activation in AKBA\u2010treated animals, further confirmed with decreased GR expression improves architecture of prefrontal cortex region. Correlation study illustrates behavioural improvements undeviating the biochemical alteration and GR expression after AKBA treatment during depression. AKBA significantly reversed the CUMS\u2010induced glutamate\/GABA abnormalities through the adaptation of central HPA axis regulation. Hence this study concludes that AKBA can be a better alternative to treat depressive disorders.<\/jats:p>","DOI":"10.1111\/1440-1681.13567","type":"journal-article","created":{"date-parts":[[2021,8,3]],"date-time":"2021-08-03T18:16:14Z","timestamp":1628014574000},"page":"1633-1641","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["3\u2010O\u2010Acetyl\u201011\u2010keto\u2010\u03b2\u2010boswellic acid ameliorates chronic unpredictable mild stress induced HPA axis dysregulation in relation with glutamate\/GABA aberration in depressive rats"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4057-520X","authenticated-orcid":false,"given":"Venkatesh","family":"Gunasekaran","sequence":"first","affiliation":[{"name":"Department of Pharmacology KMCH College of Pharmacy Coimbatore 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