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However, the cardiac effects of this heptapeptide are completely unknown. Thus, we sought to evaluate whether the <jats:italic>Bj<\/jats:italic>\u2010PRO\u20107a could protect against cardiac remodelling in spontaneously hypertensive rats (SHR). SHR were treated with <jats:italic>Bj<\/jats:italic>\u2010PRO\u20107a (71\u00a0nmol\/kg\/day, s.c.) or saline for 28\u00a0days. Wistar rats were used as control. Systolic blood pressure (SBP) and heart rate (HR) were measured by tail\u2010cuff plethysmography. Cardiomyocyte diameter and interstitial and perivascular fibrosis of the left ventricle (LV) were evaluated using Picrosirius staining. Immunofluorescence was used to detect collagen I and III. Fibroblast proliferation was assessed by immunohistochemistry to detect proliferating cell nuclear antigen (PCNA). Protein expression was assessed by western blot. The superoxide dismutase and catalase activities and the concentration of lipid peroxidation products were evaluated in the LV. The SBP and HR were not different between treated and non\u2010treated SHR at the end of the treatment. However, <jats:italic>Bj<\/jats:italic>\u2010PRO\u20107a attenuated the cardiomyocyte hypertrophy, deposition of interstitial and perivascular fibrosis and collagen I, and positive PCNA\u2010labelled fibroblasts. This peptide also reduced the increased levels of TBARS, expression and activity of catalase, and activity of SOD in LV from SHR. Also, the <jats:italic>Bj<\/jats:italic>\u2010PRO\u20107a increased the expression of metalloproteinases\u20102 in SHR hearts. These findings demonstrate that the <jats:italic>Bj<\/jats:italic>\u2010PRO\u20107a reduced the pathological cardiac remodelling in a pressure\u2010independent manner in hypertensive rats through mechanisms mediated by oxidative stress regulation.<\/jats:p>","DOI":"10.1111\/1440-1681.13577","type":"journal-article","created":{"date-parts":[[2021,8,24]],"date-time":"2021-08-24T15:50:34Z","timestamp":1629820234000},"page":"1693-1703","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Cardioprotective effects of the proline\u2010rich oligopeptide <i>Bj<\/i>\u2010PRO\u20107a in spontaneously hypertensive rats"],"prefix":"10.1111","volume":"48","author":[{"given":"\u00c9rika Fernandes","family":"de Jesus","sequence":"first","affiliation":[{"name":"Department of Physiological Sciences Institute of Biological Sciences Federal University of Goi\u00e1s Goi\u00e2nia 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