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Curcumin (Cur), a well known dietary polyphenol, could exert a significant cardioprotective effect, but the biological application of this substance is limited by its chemical insolubility. To overcome this limitation, in this study, we synthesised gold nanoparticles based on Cur (Cur\u2010AuNPs). Ultraviolet\u2010visible (UV\u2010Vis) absorbance spectroscopy and transmission electron microscopy (TEM) were performed for the characterisation of synthesised NPs, and Fourier transform infrared (FTIR) spectroscopy\u00a0were applied to detect Cur on the surface of AuNPs. Its cytotoxicity effect on H9c2 cells was evaluated using 3\u2010(4,5\u2010dimethylthiazol\u20102\u2010yl)\u20102,5\u2010diphenyltetrazolium bromide (MTT) assay. The biological efficacy of Cur\u2010AuNPs was assessed after acute cardiotoxicity induction in BALB\/c mice with DOX injection. The serum biomarkers, myocardial histological changes, and cardiomyocyte apoptosis were then measured. The results revealed that the heart protection by Cur\u2010AuNPs is more effective than Cur alone. Heart protective effect of Cur\u2010AuNPs was evident both in the short\u2010term (24\u00a0hours) and long\u2010term (14\u00a0days) study. The results of Cur\u2010AuNPs400 after 24\u00a0hours of toxicity induction displayed the reduction of the cardiac injury serum biomarkers (LDH, CK\u2010MB, cTnI, ADT, and ALT) and apoptotic proteins (Bax and Caspase\u20103), as well as increase of Bcl\u20102 anti\u2010apoptotic proteins without any sign of interfibrillar haemorrhage and intercellular spaces in the heart tissue microscopic images. Our long\u2010term study signifies that Cur\u2010AuNPs400 in DOX\u2010intoxicated mice could successfully inhibit body and heart weight loss in comparison to DOX group.<\/jats:p>","DOI":"10.1111\/1440-1681.13579","type":"journal-article","created":{"date-parts":[[2021,8,27]],"date-time":"2021-08-27T19:36:54Z","timestamp":1630093014000},"page":"70-83","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Curcumin\u2010coated gold nanoparticles attenuate doxorubicin\u2010induced cardiotoxicity via regulating apoptosis in a mouse model"],"prefix":"10.1111","volume":"49","author":[{"given":"Zeynab","family":"Sharifiaghdam","sequence":"first","affiliation":[{"name":"Student Research Committee Iran University of Medical Sciences Tehran Iran"},{"name":"Department of Physiology School of Medicine Iran University of Medical Sciences Tehran 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