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Naringin was reported to promote osteoblast differentiation, thus enhancing bone formation and alleviating osteoporosis development. However, the signalling pathways related to the regulatory mechanism of naringin in osteoporosis development are not clear. Proliferation of bone mesenchymal stem cells (BMSCs) treated with naringin in vitro was detected by CCK\u20108. An osteogenesis differentiation medium supplemented with naringin was applied to explore the effects of naringin on BMSC osteogenic differentiation, as detected by Alizarin red staining. Ovariectomy (OVX)\u2010induced postmenopausal osteoporosis (PMOP) rats were orally administered with naringin. Dual\u2010energy X\u2010ray absorptiometry (DEXA) and micro\u2010CT were applied to measure bone mineral density (BMD), bone volume\/total volume (BV\/TV), trabecula thickness (Tb.Th), trabecula number (Tb.N), trabecular separation (Tb.Sp) and bone surface\/bone volume (BS\/BV). H&amp;E staining was performed to show pathological changes of the femur in PMOP rats after naringin treatment. Bone metabolism indicators were assessed by ELISA. We found that naringin suppressed the activation of the JAK2\/STAT3 pathway. Naringin promoted BMSC proliferation and osteogenic differentiation. Furthermore, naringin alleviates bone loss and improves abnormal bone metabolism of PMOP rats. Collectively, naringin promotes BMSC osteogenic differentiation to ameliorate osteoporosis development by targeting JAK2\/STAT3\u00a0signalling.<\/jats:p>","DOI":"10.1111\/1440-1681.13591","type":"journal-article","created":{"date-parts":[[2021,9,15]],"date-time":"2021-09-15T18:37:40Z","timestamp":1631731060000},"page":"113-121","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Naringin promotes osteogenesis and ameliorates osteoporosis development by targeting JAK2\/STAT3 signalling"],"prefix":"10.1111","volume":"49","author":[{"given":"Wang","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Gynecology The Second Affiliated Hospital of Nanjing University of Chinese Medicine Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Gynecology The Second Affiliated Hospital of Nanjing 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