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The purpose of this research is to evaluate the anti\u2010cancer activity of sodium salt of ethyl (E)\u20102\u2010cyano\u20103\u2010(7\u2010hydroxy\u20104\u2010methyl\u20102\u2010oxoquinoline\u20101(2H)\u2010yl)\u20103\u2010(4\u2010hydroxyphenyl) acrylate against Ehrlich ascites carcinoma (EAC) cells residing in female mice's peritoneal cavity. The docking study exhibited a favourable interaction between the compound and the receptors 1MOY and 3KJF of osteopontin and caspase 3, respectively. The compound's sodium salt showed potential antioxidant and anti\u2010cancer effects against Ehrlich ascites carcinoma (EAC) cells in vivo. Herein, the results elucidated that treatment with the compound's sodium salt exerted significant chemopreventive and chemotherapeutic effects, which reduced both EAC cell volume and count. Our results revealed that treatment with the sodium salt of the compound demonstrated a remarkable in vivo apoptotic effect through elevation of the expression of caspase 3 and reduction of osteopontin levels. Histopathological examination confirmed that the compound's sodium salt improved liver and kidney tissues without any apparent adverse effects.<\/jats:p>","DOI":"10.1111\/1440-1681.13592","type":"journal-article","created":{"date-parts":[[2021,9,18]],"date-time":"2021-09-18T17:24:01Z","timestamp":1631985841000},"page":"145-174","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["<i>In vivo<\/i> biological evaluation of sodium salt of ethyl (<i>E<\/i>)\u20102\u2010cyano\u20103\u2010(7\u2010hydroxy\u20104\u2010methyl\u20102\u2010oxoquinoline\u20101(<i>2H<\/i>)\u2010yl)\u20103\u2010(4\u2010hydroxyphenyl) acrylate as anticancer agent"],"prefix":"10.1111","volume":"49","author":[{"given":"Faten Z.","family":"Mohammed","sequence":"first","affiliation":[{"name":"Chemistry Department (Biochemistry Branch) Faculty of Science Zagazig University Zagazig 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