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There are very few publications that show the presence of TTX\u2010resistant sodium currents in central neurons. The aim of this study was to assess if functional Nav1.8\u00a0TTX\u2010resistant sodium currents are expressed in prefrontal cortex pyramidal neurons. All recordings were performed in the presence of TTX in the extracellular solution to block TTX\u2010sensitive sodium currents. The TTX\u2010resistant sodium current recorded in this study was mainly carried by the Nav1.8\u00a0sodium channel isoform because the Nav1.9 current was inhibited by the \u221265\u00a0mV holding potential that we used throughout the study. Moreover, the sodium current that we recorded was inhibited by treatment with the selective Nav1.8 inhibitor A\u2010803467. Confocal microscopy experiments confirmed the presence of the Nav1.8 \u03b1 subunit in prefrontal cortex pyramidal neurons. Activation and steady state inactivation properties of TTX\u2010resistant sodium currents were also assessed in this study and they were similar to activation and inactivation properties of TTX\u2010resistant sodium currents expressed in dorsal root ganglia (DRG) neurons. Moreover, this study showed that carbamazepine (60\u00a0\u00b5M) inhibited the maximal amplitude of the TTX\u2010resistant sodium current. Furthermore, we found that carbamazepine shifts steady state inactivation curve of TTX\u2010resistant sodium currents toward hyperpolarization. This study suggests that the Nav1.8\u00a0TTX\u2010resistant sodium channel is expressed not only in DRG neurons, but also in cortical neurons and may be molecular target for antiepileptic drugs such as carbamazepine.<\/jats:p>","DOI":"10.1111\/1440-1681.13610","type":"journal-article","created":{"date-parts":[[2021,11,9]],"date-time":"2021-11-09T09:00:25Z","timestamp":1636448425000},"page":"350-359","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Prefrontal cortex pyramidal neurons express functional Nav1.8 tetrodotoxin\u2010resistant sodium currents"],"prefix":"10.1111","volume":"49","author":[{"given":"Bart\u0142omiej","family":"Szulczyk","sequence":"first","affiliation":[{"name":"Department of Pharmacodynamics The Medical University of Warsaw Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Micha\u0142","family":"Pasierski","sequence":"additional","affiliation":[{"name":"Department 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