{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T02:08:45Z","timestamp":1780452525592,"version":"3.54.1"},"reference-count":42,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002386","name":"Cairo University","doi-asserted-by":"publisher","award":["CU#721"],"award-info":[{"award-number":["CU#721"]}],"id":[{"id":"10.13039\/501100002386","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Exp Pharma Physio"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cardiac dysfunction is one of the leading causes of death in epilepsy. The anti\u2010arrhythmic drug, amiodarone, is under investigation for its therapeutic effects in epilepsy. We aimed to evaluate the possible effects of amiodarone on cardiac injury during status epilepticus, as it can cause prolongation of the QT interval. Five rat groups were enrolled in the study; three control groups (1) Control, (2) Control\u2010lithium and (3) Control\u2010Amio, treated with 150\u00a0mg\/kg\/intraperitoneal amiodarone, (4) Epilepsy model, induced by sequential lithium\/pilocarpine administration, and (5) the epilepsy\u2010Amio group. The model group expressed a typical clinical picture of epileptiform activity confirmed by the augmented electroencephalogram alpha and beta spikes. The anticonvulsive effect of amiodarone was prominent, it diminished (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) the severity of seizures and hence, deaths and reduced serum noradrenaline levels. In the model group, the electrocardiogram findings revealed tachycardia, prolongation of the corrected QT (QTc) interval, depressed ST segments and increased myocardial oxidative stress. The in\u2010vitro myocardial performance (contraction force and \u2013 (df\/dt)<jats:sub>max<\/jats:sub>) was also reduced. Amiodarone decreased (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) the heart rate, improved ST segment depression, and myocardial contractility with no significant change in the duration of the QTc interval. Amiodarone preserved the cardiac histological structure and reduced the myocardial injury markers represented by serum Troponin\u2010I, oxidative stress and IL\u20101. Amiodarone pretreatment prevented the anticipated cardiac injury induced during epilepsy. Amiodarone possessed an anticonvulsive potential, protected the cardiac muscle and preserved its histological architecture. Therefore, amiodarone could be recommended as a protective therapy against cardiac dysfunction during epileptic seizures with favourable effect on seizure activity.<\/jats:p>","DOI":"10.1111\/1440-1681.13615","type":"journal-article","created":{"date-parts":[[2021,11,19]],"date-time":"2021-11-19T10:06:47Z","timestamp":1637316407000},"page":"406-418","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Cardioprotective effects of amiodarone in a rat model of epilepsy\u2010induced cardiac dysfunction"],"prefix":"10.1111","volume":"49","author":[{"given":"Inas A.","family":"Harb","sequence":"first","affiliation":[{"name":"Department of Medical Pharmacology Faculty of Medicine Cairo University  Cairo 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