{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T08:05:40Z","timestamp":1777363540664,"version":"3.51.4"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,12,27]],"date-time":"2021-12-27T00:00:00Z","timestamp":1640563200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004281","name":"Narodowe Centrum Nauki","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Exp Pharma Physio"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The contribution of angiotensin (1\u20137) (Ang1\u20107) to control of extrarenal and renal function may be modified in diabetes. We investigated the effects of Ang1\u20107\u00a0supplementation on blood pressure, renal circulation and intrarenal reactivity (IVR) to vasoactive agents in normoglycaemic (NG) and streptozotocin diabetic rats (DM). In Sprague Dawley DM and NG rats, 3\u00a0weeks after streptozotocin (60\u00a0mg\/kg i.p.) or solvent injection, Ang1\u20107 was administered (400\u00a0ng\/min) over the next 2\u00a0weeks using subcutaneously implanted osmotic minipumps. For a period of 5\u00a0weeks, blood pressure (BP), 24\u00a0h water intake and diuresis were determined weekly. In anaesthetised rats, BP, renal total and cortical (CBF), outer (OMBF) and inner medullary (IMBF) perfusion and urine excretion were determined. To check IVR, a short\u2010time infusion of acetylcholine or norepinephrine was randomly given to the renal artery. Unexpectedly, BP did not differ between NG and DM, and this was not modified by Ang\u20101\u20137 supplementation. Baseline IMBF was higher in NG vs. DM, and Ang1\u20107 treatment did not change it in NG but decreased it in DM. In the latter, Ang1\u20107 increased cortical IVR to vasoconstrictor and vasodilator stimuli. IMBF decrease after high acetylcholine dose seen in untreated NG was reverted to an increase in Ang1\u20107 treated rats. Irrespective of the glycaemia level, Ang1\u20107 did not modify BP. However, it impaired medullary circulation in DM, whereas in NG it rendered the medullary vasculature more sensitive to vasodilators. Possibly, the medullary hypoperfusion in DM was mediated by Ang1\u20107 activation of angiotensin AT\u20101 receptors which are upregulated by hyperglycaemia.<\/jats:p>","DOI":"10.1111\/1440-1681.13618","type":"journal-article","created":{"date-parts":[[2021,12,6]],"date-time":"2021-12-06T14:00:29Z","timestamp":1638799229000},"page":"432-441","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Role of Ang1\u20107 in renal haemodynamics and excretion in streptozotocin diabetic rats"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6156-1571","authenticated-orcid":false,"given":"Marta","family":"Kuczeriszka","sequence":"first","affiliation":[{"name":"Department of Renal and Body Fluid Physiology Mossakowski Medical Research Institute, Polish Academy of Sciences  Warsaw 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