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However, the association between the retinal degeneration resulting from the abnormality of FBN2 and the activation of TGF\u2010\u03b2 signalling has not been fully addressed. In the present study, the mice were divided into a normal control group (NC group), a phosphate\u2010buffered saline (PBS) injection group (PBS group), and an anti\u2010FBN2 protein injection group (anti\u2010FBN2\u00a0group), and the mice in PBS and anti\u2010FBN2\u00a0groups received the relevant treatment via the intravitreal injection once a week for three consecutive weeks. One week later after injection, the retinal morphology and visual function of the fundus were detected. Further, the expression of FBN2, TGF\u2010\u03b21, TGF\u2010\u03b22 and TGF\u2010\u03b23 in retina was measured using quantitative polymerase chain reaction and enzyme\u2010linked immunosorbent assay (ELISA), respectively. As a result, fundus examination suggests that after intravitreous injection of anti\u2010FBN2 protein, there were a large patchy yellow white degeneration region and numerous pigmentations in the retina in anti\u2010FBN2\u2010treated mice; by contrast, there was no apparent change in mice from the NC and PBS groups. The retina suffered markedly damage, and the thickness of whole retina and outer nuclear layer markedly thinned. The expression of FBN2 was decreased whereas the levels of TGF\u2010\u03b21, TGF\u2010\u03b22 and TGF\u2010\u03b23 were upregulated. Together, our findings indicate that the intravitreous delivery of anti\u2010FBN2 protein could induce retina degeneration in mice, accompanied by the higher activated TGF\u2010\u03b2. The retinal degeneration mouse model established will provide a platform for the investigation of the retinal diseases.<\/jats:p>","DOI":"10.1111\/1440-1681.13631","type":"journal-article","created":{"date-parts":[[2022,2,2]],"date-time":"2022-02-02T18:31:33Z","timestamp":1643826693000},"page":"586-595","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Association between anti\u2010fibrillin\u20102 protein induced retinal degeneration via intravitreous delivery and activated TGF\u2010\u03b2 signalling in mice"],"prefix":"10.1111","volume":"49","author":[{"given":"Furu","family":"Xu","sequence":"first","affiliation":[{"name":"Affiliated Eye Hospital of Shandong University of Traditional Chinese Medicine Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dadong","family":"Guo","sequence":"additional","affiliation":[{"name":"Shandong Provincial Key Laboratory of Integrated Traditional Chinese 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