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Angiotensin II (AngII) results in cardiac fibrosis and hypertrophy partly through activation of inflammation, which increases the fibroblasts and promotes extracellular matrix production. Sulfasalazine (SASP) has evident anti\u2010inflammatory effects and pharmacological functions on autoimmune disease. The roles of SASP in the cardiac remodelling remain unknown. In this study, we established AngII\u2010induced cardiac remodelling mice model and then treated with SASP. Blood pressure, cardiac pump function and pathological changes of cardiac remodelling were analysed in these mice. To explore the mechanism, phosphorylated Akt was detected in vivo and vitro. In this study, we found that SASP aggravated cardiac dysfunction, hypertrophy and fibrosis after AngII infusion. In addition, SASP activated Akt in AngII\u2010remodelled mouse hearts and cardiac cells. Our findings indicate that independent of anti\u2010inflammatory property, SASP exacerbates AngII\u2010induced cardiac remodelling by activation of Akt signalling pathway.<\/jats:p>","DOI":"10.1111\/1440-1681.13653","type":"journal-article","created":{"date-parts":[[2022,5,11]],"date-time":"2022-05-11T07:40:29Z","timestamp":1652254829000},"page":"776-783","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Sulfasalazine exacerbates angiotensin <scp>II<\/scp>\u2010induced cardiac remodelling by activating Akt signal pathway"],"prefix":"10.1111","volume":"49","author":[{"given":"Chen","family":"Chen","sequence":"first","affiliation":[{"name":"China\u2010America Institute of Neuroscience, Beijing Luhe Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Beijing 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