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In addition to, it evaluated whether a post\u2010weaning enriched environment (EE) would affect the nicotine\u2010induced conditioned place preference (CPP) and the motor and cognitive deficits caused by MK\u2010801 treatment. Male Wistar rat pups were injected peritoneally with MK\u2010801 (1\u2009mg\/kg) on a daily basis between the 6th and the 10th postnatal days (P) and were exposed to either an enriched or a standard cage from P21 until the end of the experiments. The rats were evaluated in open\u2010field and three\u2010chamber social interaction tests. Moreover, spatial and reversal learning was assessed by the Morris water maze (MWM). The animals were conditioned with 0.6\u2009mg\/kg nicotine and tested for CPP. Increased self\u2010grooming, exploratory behaviour, potentiated nicotine\u2010CPP and decreased social behaviours, delayed spatial learning and memory and impaired reversal learning in the water maze were observed in the MK\u2010801 treatment group. Housing in an EE improved cognitive and behavioural deficits associated with postnatal MK\u2010801 treatment. The results suggested that neonatal <jats:italic>N<\/jats:italic>\u2010methyl\u2010<jats:sc>d<\/jats:sc>\u2010aspartate (NMDA) receptor hypofunction may cause susceptibility to these behaviours and indicated the importance of environmental conditions in the development of schizophrenia and probably other neuropsychiatric disorders.<\/jats:p>","DOI":"10.1111\/1440-1681.13674","type":"journal-article","created":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T16:54:20Z","timestamp":1653670460000},"page":"871-880","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Nicotine\u2010conditioned place preference, reversal learning and social interaction in <scp>MK<\/scp>\u2010801\u2010induced schizophrenia model: Effects of post\u2010weaning enriched environment"],"prefix":"10.1111","volume":"49","author":[{"given":"Neda","family":"Salmani","sequence":"first","affiliation":[{"name":"Department of Psychology, Zarand Branch 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