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The aim of this work was to study the effect of a low molecular weight systemically active nerve growth factor mimetic, compound GK\u20102 (hexamethylenediamide bis[N\u2010monosuccinyl\u2010L\u2010glutamyl\u2010L\u2010lysine]), on indicators of abdominal obesity, basal blood glucose level, glucose tolerance, cholesterol and triglyceride blood levels, as well as the morphological structure of the liver in male<jats:italic>Wistar<\/jats:italic>rats fed a HFD. Rats were divided into three groups: one of them received standard food (control) and two others were fed a HFD containing 45% fat, 35% carbohydrates and 20% protein, with a total caloric value of 516\u2009kcal\/100\u2009g, over 12\u2009weeks. Starting from the ninth week, for the next 4\u2009weeks, one of the HFD groups was treated orally with saline whilst the other group was treated orally with GK\u20102 at a dose of 5\u2009mg\/kg. GK\u20102 was found to reduce the basal glycaemia level and improve glucose tolerance, as well as to reduce the blood level of cholesterol by 30% and that of triglycerides by 28% in comparison with the saline\u2010treated HFD animals. GK\u20102 reduced the degree of abdominal obesity to the level of the healthy animals and eliminated morphological abnormalities in the liver caused by the HFD. The results of the study determine the feasibility of further GK\u20102 research as a potential agent for prediabetes treatment.<\/jats:p>","DOI":"10.1111\/1440-1681.13693","type":"journal-article","created":{"date-parts":[[2022,6,24]],"date-time":"2022-06-24T14:18:46Z","timestamp":1656080326000},"page":"1116-1125","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Low molecular weight<scp>NGF<\/scp>mimetic<scp>GK<\/scp>\u20102 normalizes the parameters of glucose and lipid metabolism and exhibits a hepatoprotective effect on a prediabetes model in obese Wistar rats"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0438-9108","authenticated-orcid":false,"given":"Sergei V.","family":"Ivanov","sequence":"first","affiliation":[{"name":"V.V. 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