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Sirtuin 1 (SIRT1) plays an important role in chondrocyte function and homeostasis. Thus, we further explored the regulatory mechanism of SIRT1 in Dex\u2010induced growth plate chondrocyte dysfunction. SIRT1 expression was detected in Dex\u2010treated growth plate chondrocytes using RT\u2010qPCR and western blot assay. The modulation of SIRT1 on SOX2 expression was evaluated. Besides, we identified that SIRT1 was targeted by miR\u2010211\u20105p using TargetScan and RNA pull\u2010down assay. A loss\u2010of\u2010function assay was performed to evaluate the effects of miR\u2010211\u20105p on Dex\u2010induced growth plate chondrocyte dysfunction in vitro and in vivo. We found that SIRT1 was downregulated in Dex\u2010treated growth plate chondrocytes. The expression of SOX2 was upregulated by overexpression SIRT1. Meanwhile, downregulation of SOX2 weakened the positive function of SIRT1 overexpression on Dex\u2010induced growth plate chondrocytes dysfunction. Subsequently, we confirmed that SIRT1 was targeted by miR\u2010211\u20105p. MiR\u2010211\u20105p inhibitor increased the expression levels of SIRT1 and SOX2, and restored the Dex\u2010treated growth plate chondrocyte function. Animal assays further demonstrated that the effects of miR\u2010211\u20105p on the growth plate chondrogenesis. In conclusion, our data suggest that SIRT1 exerts a protective effect on growth plate chondrocyte under Dex stimulation. MiR\u2010211\u20105p\/SIRT1\/SOX2 axis regulates the process of Dex\u2010inhibited growth plate chondrogenesis.<\/jats:p>","DOI":"10.1111\/1440-1681.13721","type":"journal-article","created":{"date-parts":[[2022,9,10]],"date-time":"2022-09-10T08:14:33Z","timestamp":1662797673000},"page":"50-58","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["<scp>SIRT1<\/scp> targeted by <scp>miR<\/scp>\u2010211\u20105p regulated proliferation and apoptosis of Dex\u2010treated growth plate chondrocytes via mediating <scp>SOX2<\/scp>"],"prefix":"10.1111","volume":"50","author":[{"given":"Deliang","family":"Cheng","sequence":"first","affiliation":[{"name":"Department of Hand Surgery Honghui Hospital, Xi'an Jiaotong University  Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lijun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hand Surgery Honghui Hospital, Xi'an Jiaotong 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