{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T16:32:49Z","timestamp":1790181169246,"version":"4.1.0"},"reference-count":57,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,2,10]],"date-time":"2023-02-10T00:00:00Z","timestamp":1675987200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Exp Pharma Physio"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Gastric ulcer is the most common gastrointestinal disorder affecting people globally. Although many drugs are available to treat ulcers, the mortality rate is relatively high, and drugs lack selectivity to treat ulcers without causing side effects. In this study, the potential therapeutic effects of phylloquinone were tested against indomethacin\u2010induced gastric ulcer in rats by giving rats a single oral dose of indomethacin (48\u2009mg\/kg), followed by phylloquinone (10\u00a0mg\/kg) orally, once daily for six consecutive days. Phylloquinone significantly attenuated indomethacin\u2010induced oxidative and inflammatory responses through hindering the inflammatory cascade by decreasing the levels of TNF\u2010\u03b1, NF\u2010\u03baB, INOS and COX\u20102 which counteracts indomethacin effects. Also, it increased NAD<jats:sup>+<\/jats:sup> which enhanced SIRT\u20101 level. Furthermore, phylloquinone was effective in increasing mucus secretion, decreasing acid secretion, reversing histological effects caused by indomethacin and minimizing ulcer and lesion indices All these findings indicate that phylloquinone may be used in protection and treatment of indomethacin\u2010induced gastric ulcer.<\/jats:p>","DOI":"10.1111\/1440-1681.13752","type":"journal-article","created":{"date-parts":[[2023,1,17]],"date-time":"2023-01-17T14:33:59Z","timestamp":1673966039000},"page":"369-379","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effect of phylloquinone on indomethacin\u2010induced gastric ulceration in rats: Role of <scp>SIRT<\/scp>\u20101"],"prefix":"10.1111","volume":"50","author":[{"given":"Sara E.","family":"Hamza","sequence":"first","affiliation":[{"name":"Egyptian Drug Authority  Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara A.","family":"Wahdan","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Pharmacy Ain Shams University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ebtehal","family":"El\u2010Demerdash","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Pharmacy Ain Shams University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,2,10]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"219","article-title":"Peptic ulcer disease and helicobacter pylori infection","volume":"115","author":"Narayanan M","year":"2018","journal-title":"Mo Med"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)32404-7"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2003.10.011"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1472-8206.2003.00135.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2011.12.023"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2013.08.047"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2015.05.023"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2006.11.006"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2007.1630"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.081067"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1650608"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2013.01.012"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbapap.2010.05.002"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxins2112490"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7600244"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8223(96)00044-2"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-2797(00)00199-X"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-12-92"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2015.05.012"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000322643"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2009.27930"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2014.05.012"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0102-86502014000800007"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.4103\/0253-7613.135953"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.14.2487"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S44108"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-009-9176-5"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(02)00995-4"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1179\/135100006X155021"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13105-013-0241-z"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2015.03.006"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2020.590088"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000142232.29764.a7"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(97)00254-2"},{"issue":"4","key":"e_1_2_7_36_1","first-page":"726","article-title":"Prooxidant activities of antioxidants and their impact on health","volume":"58","author":"Sotler R","year":"2019","journal-title":"Acta Clin Croat"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.08-109355"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2785"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.2001.280.6.G1296"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2009.09.011"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1012779530004"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevEukarGeneExpr.v20.i2.10"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1159\/000007752"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2009.06047.x"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2017.11.008"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-2308"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612043453144"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(99)00115-1"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.49.3.443"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10071571"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0928-4257(01)00034-1"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.118272"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.658263"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1080\/07853890701408194"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1177\/1947601912475079"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2015.01.008"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2007.09.041"},{"key":"e_1_2_7_58_1","first-page":"330","article-title":"Ulcer protective potential of standardized hesperidin, a citrusflavonoid isolated from citrus sinensi","volume":"24","author":"Papiya B","year":"2014","journal-title":"Rev Bras Pharm J"}],"container-title":["Clinical and Experimental Pharmacology and Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1440-1681.13752","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1440-1681.13752","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1440-1681.13752","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T02:37:11Z","timestamp":1692671831000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1440-1681.13752"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,10]]},"references-count":57,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["10.1111\/1440-1681.13752"],"URL":"https:\/\/doi.org\/10.1111\/1440-1681.13752","archive":["Portico"],"relation":{},"ISSN":["0305-1870","1440-1681"],"issn-type":[{"value":"0305-1870","type":"print"},{"value":"1440-1681","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,10]]},"assertion":[{"value":"2022-04-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}