{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:44:02Z","timestamp":1791920642611,"version":"4.3.4"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,1,31]],"date-time":"2023-01-31T00:00:00Z","timestamp":1675123200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82274339"],"award-info":[{"award-number":["82274339"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81873134"],"award-info":[{"award-number":["81873134"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Exp Pharma Physio"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Senescence of activated hepatic stellate cells (aHSCs) is a stable growth arrest that is implicated in liver fibrosis regression. Senescent cells often accompanied by a multi\u2010faceted senescence\u2010associated secretory phenotype (SASP). Induction of aHSCs senescence by inhibiting SASP may be a potential therapeutic model against hepatic fibrosis. To evaluate the role of atractylenolide III (ATR III) in the development of chemotherapeutic drug\u2010induced SASPs in hepatic stellate cells. Etoposide\u2010induced senescent HSC\u2010LX2 model was established and treated with ATR III at different concentrations (20, 30 and 40\u2009\u03bcM). We found that ATR III dose\u2010dependently enhanced senescence in etoposide\u2010induced LX2 cells. ATR III dose\u2010dependently decreased the release and expression of SASP factors (interleukin [IL]\u20101\u03b1, IL\u20101\u03b2, IL6 and IL\u20108) in senescent cells. ATR III regulated cyclic GMP\u2010AMP synthase (cGAS)\/nuclear factor \u03ba (NF\u2010\u03baB) signalling to affect SASP expression in senescent cells. The addition of 2'3\u2032 cGAMP counteracted the effect of ATR III. The release of SASP factors in the conditioned medium from senescent cells could affect cell migration, proliferation and contraction through paracrine manner. Our results indicated ATR III could still enter senescence and prevent the production of SASP and its paracrine effects in senescent cells, an effect that may be related to the possible inhibition of cGAS\/NF\u2010\u03baB signalling by ATR III. Our study proves that ATR III may be an effective potential drug against liver fibrosis by promoting aHSC senescence, which can provide a new choice for the future clinical treatment of liver fibrosis.<\/jats:p>","DOI":"10.1111\/1440-1681.13753","type":"journal-article","created":{"date-parts":[[2023,1,17]],"date-time":"2023-01-17T09:54:12Z","timestamp":1673949252000},"page":"316-324","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Atractylenolide\n                    <scp>III<\/scp>\n                    suppresses senescence\u2010associated secretome via inhibiting\n                    <scp>cGAS<\/scp>\n                    \/\n                    <scp>NF\u2010\u03baB<\/scp>\n                    pathway in hepatic stellate cells"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0184-2360","authenticated-orcid":false,"given":"Hongyan","family":"Wu","sequence":"first","affiliation":[{"name":"Institute of Biomedical Technology Jiangsu Vocational College of Medicine  Yancheng China"},{"name":"School of Pharmacology Jiangsu Vocational College of Medicine  Yancheng China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixia","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Lujiang People's Hospital  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linxia","family":"Xiao","sequence":"additional","affiliation":[{"name":"School of Pharmacology Jiangsu Vocational College of Medicine  Yancheng China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaqin","family":"Gu","sequence":"additional","affiliation":[{"name":"School of Pharmacology Jiangsu Vocational College of Medicine  Yancheng China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongxia","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Pharmacology Jiangsu Vocational College of Medicine  Yancheng China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Technology Jiangsu Vocational College of Medicine  Yancheng China"},{"name":"School of Pharmacology Jiangsu Vocational College of Medicine  Yancheng China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingguang","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Pharmacology Jiangsu Vocational College of Medicine  Yancheng China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Qi","sequence":"additional","affiliation":[{"name":"School of Pharmacology Jiangsu Vocational College of Medicine  Yancheng China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,1,31]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2017.38"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00013.2007"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.06.036"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1201840109"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.10.005"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2016.10.002"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2016.92"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.211053698"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/08923973.2020.1806871"},{"key":"e_1_2_9_11_1","first-page":"1875471","article-title":"Atractylenolide III attenuates muscle wasting in chronic kidney disease via the oxidative stress\u2010mediated PI3K\/AKT\/mTOR pathway","volume":"2019","author":"Wang M","year":"2019","journal-title":"Oxid Med Cell Longev"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-019-0324-8"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.15289"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0052305"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-012-0928-2"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2011.04.018"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.25744"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26993"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2019.01.013"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-121808-102144"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2018.09.013"}],"container-title":["Clinical and Experimental Pharmacology and Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1440-1681.13753","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1440-1681.13753","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1440-1681.13753","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,18]],"date-time":"2023-08-18T16:08:06Z","timestamp":1692374886000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1440-1681.13753"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,31]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["10.1111\/1440-1681.13753"],"URL":"https:\/\/doi.org\/10.1111\/1440-1681.13753","archive":["Portico"],"relation":{},"ISSN":["0305-1870","1440-1681"],"issn-type":[{"value":"0305-1870","type":"print"},{"value":"1440-1681","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,31]]},"assertion":[{"value":"2022-10-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}