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RyRs are highly expressed in immune cells and are involved in different viral infections, including severe acute respiratory syndrome coronavirus type 2 (SARS\u2010CoV\u20102), because Ca<jats:sup>2+<\/jats:sup> is necessary for viral replication, maturation and release. DTN can inhibit the proliferation of SARS\u2010CoV\u20102, indicating its potential role in reducing entry and pathogenesis of SARS\u2010CoV\u20102. DTN may increase clearance of SARS\u2010CoV\u20102 and promote coronavirus disease 2019 (COVID\u201019) recovery by shortening the period of infection. DTN inhibits N\u2010methyl\u2010D\u2010aspartate (NMDA) mediated platelets aggregations and thrombosis. Therefore, DTN may inhibit thrombosis and coagulopathy in COVID\u201019 through suppression of platelet NMDA receptors. Moreover, DTN has a neuroprotective effect against SARS\u2010CoV\u20102 infection\u2010induced brain injury through modulation of NMDA receptors, which are involved in excitotoxicity, neuronal injury and the development of neuropsychiatric disorders. In conclusion, DTN by inhibiting RyRs may attenuate inflammatory disorders in SARS\u2010CoV\u20102 infection and associated cardio\u2010pulmonary complications. Therefore, DNT could be a promising drug therapy against COVID\u201019. 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