{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:22:39Z","timestamp":1747182159957,"version":"3.40.5"},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,3,8]],"date-time":"2023-03-08T00:00:00Z","timestamp":1678233600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Exp Pharma Physio"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Postpartum haemorrhage remains a significant cause of maternal morbidity and mortality with the commonest reason being uterine atony. For prevention of uterine atony during caesarean delivery, oxytocin is advocated as a first line drug. There is however no published data regarding utility of a weight\u2010based oxytocin infusion. The present study evaluated dose\u2013response relationship for oxytocin infusion when used as weight\u2010based regimen. A total of 55 non\u2010labouring patients without risk factors for uterine atony and scheduled for caesarean delivery under spinal anaesthesia were enrolled. Randomization was done to receive oxytocin infusion in a dose of 0.1, 0.15, 0.2, 0.25 or 0.3\u00a0IU\u2009kg<jats:sup>\u22121<\/jats:sup>\u00a0h<jats:sup>\u22121<\/jats:sup> (<jats:italic>n<\/jats:italic>\u00a0=\u00a011 each), initiated at the time of cord clamping and continued until the end of surgery. Successful outcome was defined as attaining an adequate uterine response at 4\u00a0min of initiation of infusion and maintained till end of surgery. Oxytocin associated hypotension, tachycardia, ST\u2010T changes, nausea\/vomiting, flushing and chest pain were also observed. A significant linear trend for adequate intraoperative uterine tone was seen with increasing dose of weight\u2010based oxytocin infusion (P\u2009&lt;\u20090.001). The effective dose in 90% population (ED90) was 0.29\u2009IU\u2009kg<jats:sup>\u22121<\/jats:sup>\u00a0h<jats:sup>\u22121<\/jats:sup> (95% CI\u00a0=\u00a00.25\u20130.42). Amongst the oxytocin associated side effects, a significant linear trend was seen between increasing dose of oxytocin infusion and hypotension as well as nausea\/vomiting (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.016 and 0.023 respectively). Thus, oxytocin infusion during caesarean delivery may be used as per the patient's body weight.<\/jats:p>","DOI":"10.1111\/1440-1681.13766","type":"journal-article","created":{"date-parts":[[2023,2,27]],"date-time":"2023-02-27T08:53:20Z","timestamp":1677488000000},"page":"497-503","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Weight\u2010based oxytocin infusion for preventing uterine atony during caesarean delivery in non\u2010labouring patients: A dose\u2013response study"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0992-3181","authenticated-orcid":false,"given":"Surbhi","family":"Tyagi","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology &amp; Critical Care University College of Medical Sciences &amp; GTB Hospital  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asha","family":"Tyagi","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology &amp; Critical Care University College of Medical Sciences &amp; GTB Hospital  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salhotra","family":"Rashmi","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology &amp; Critical Care University College of Medical Sciences &amp; GTB Hospital  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Medha","family":"Mohta","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology &amp; Critical Care University College of Medical Sciences &amp; GTB Hospital  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bindiya","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology University College of Medical Sciences &amp; GTB Hospital  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,3,8]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12630-010-9297-1"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.14178"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/AIA.0000000000000016"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.14757"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000191529.52596.c0"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000142709.04450.bd"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000000682"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000000781"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/ael302"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(01)01479-X"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijoa.2009.08.005"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/01443615.2020.1780421"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jmwh.12935"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.15322"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000004282"}],"container-title":["Clinical and Experimental Pharmacology and Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1440-1681.13766","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1440-1681.13766","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1440-1681.13766","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T05:23:45Z","timestamp":1692681825000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1440-1681.13766"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,8]]},"references-count":15,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["10.1111\/1440-1681.13766"],"URL":"https:\/\/doi.org\/10.1111\/1440-1681.13766","archive":["Portico"],"relation":{},"ISSN":["0305-1870","1440-1681"],"issn-type":[{"type":"print","value":"0305-1870"},{"type":"electronic","value":"1440-1681"}],"subject":[],"published":{"date-parts":[[2023,3,8]]},"assertion":[{"value":"2022-12-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}