{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T21:39:18Z","timestamp":1775165958855,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,3,27]],"date-time":"2023-03-27T00:00:00Z","timestamp":1679875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Exp Pharma Physio"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Many preclinical studies reported that the carboxyl terminus of Hsp70\u2010interacting protein (CHIP) has cardiovascular protective effects. This study was designed to explore whether CHIP is related with cardiovascular disease (CVD) in maintanence haemodialysis (MHD) patients. 217 MHD patients and 150 healthy controls were recruited, serum CHIP concentration and clinical characteristics were measured. MHD patients were followed\u2010up for 36\u2009months and their cardiovascular events (CVEs) and survival conditions were recorded. Here, the data shows that serum CHIP concentrations in MHD patients were lower than those in healthy controls (31.69\u2009\u00b1\u200918.2\u2009pg\/mL vs 84.53\u2009\u00b1\u200922.1\u2009pg\/mL, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). CHIP negatively correlated with age, C\u2010reactive protein, B\u2010type brain natriuretic peptide, phosphorus, parathyroid hormone, carotid intima\u2010media thickness (CIMT) and left ventricular septal thickness (LVSTd), whereas it positively associated with albumin, haemoglobin, creatinine, Kt\/V and ejection fraction (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05, respectively). Partial correlation and multiple linear regression analysis verified the negative relationship between CHIP with CIMT or LVSTd (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05, respectively). Using quartile method and Kaplan\u2013Meier survival function, it indetified that the lower serum CHIP concentration predicted risk of CVEs, CVD and all\u2010cause death (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Cox regression analysis manifested CHIP was negatively associated with CVEs (HR\u00a0=\u00a00.914, 95%CI 0.880\u20130.950, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), CVD mortality (HR\u00a0=\u00a00.747, 95%CI 0.651\u20130.857, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and all\u2010cause death (HR\u00a0=\u00a00.769, 95%CI 0.696\u20130.850, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). In conclusion, the data of this study revealed that serum CHIP level is significantly correlated with multiple risk factors of CVD and may be one of the predictors of CVD risk and death in MHD patients.<\/jats:p>","DOI":"10.1111\/1440-1681.13770","type":"journal-article","created":{"date-parts":[[2023,3,14]],"date-time":"2023-03-14T07:25:31Z","timestamp":1678778731000},"page":"527-538","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Relationship between serum <scp>CHIP<\/scp> levels with cardiovascular disease in maintenance haemodialysis patients"],"prefix":"10.1111","volume":"50","author":[{"given":"Taijing","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Nephrology the People's Hospital of Huishan District in Wuxi  Jiangsu Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengjun","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Shanghai East Hospital Tongji University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinhui","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Nephrology the People's Hospital of Pudong New District in Shanghai  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shenglei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Shanghai East Hospital Tongji University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuchen","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Shanghai East Hospital Tongji University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Shanghai East Hospital Tongji University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Shanghai East Hospital Tongji University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yide","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Laboratory Shanghai East Hospital, Tongji University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"He","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Shanghai East Hospital Tongji University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuan","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Shanghai East Hospital Tongji University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Shanghai East Hospital Tongji University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,3,27]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"StatPearls","author":"Murdeshwar HN","year":"2022"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/sdi.12694"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.14206"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/918183"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000343361"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2017.02.047"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbf.2962"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI69080"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2013.90"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1103114"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40620-021-01068-0"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-18980-x"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.8219"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-020-02953-5"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/08830185.2017.1309528"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.29424"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.3747\/pdi.2018.00227"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfy174"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.51569"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2013.1131"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfac212"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA120.014976"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23063346"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ypmed.2021.106819"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.635086"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41374-022-00786-8"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep40023"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0135691"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.04860709"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.109.214346"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1379\/CSC-90R.1"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.24.2.856-864.2004"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajh.2012.74"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.540559"}],"container-title":["Clinical and Experimental Pharmacology and Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1440-1681.13770","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1440-1681.13770","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T05:23:59Z","timestamp":1692681839000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1440-1681.13770"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,27]]},"references-count":34,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["10.1111\/1440-1681.13770"],"URL":"https:\/\/doi.org\/10.1111\/1440-1681.13770","archive":["Portico"],"relation":{},"ISSN":["0305-1870","1440-1681"],"issn-type":[{"value":"0305-1870","type":"print"},{"value":"1440-1681","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,27]]},"assertion":[{"value":"2022-10-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}