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The use of tetracyclines has received renewed attention in recent years, and this study was designed to investigate the antibacterial activity of omadacycline, eravacycline, tigecycline, sarecycline, minocycline and doxycycline against <jats:italic>M. avium<\/jats:italic>, <jats:italic>M. intracellulare<\/jats:italic> and <jats:italic>M. kansasii<\/jats:italic>. Susceptibility testing of six tetracyclines was conducted against <jats:italic>M. avium<\/jats:italic>, <jats:italic>M. intracellulare<\/jats:italic> and <jats:italic>M. kansasii<\/jats:italic> isolates, and all the clinical isolates were collected from January 2012 to December 2018. All six agents exhibited poor antibacterial activity against slowly growing mycobacteria (SGM) isolates of three subspecies with MIC<jats:sub>50<\/jats:sub> and MIC<jats:sub>90<\/jats:sub>\u2009\u22658\u2009\u03bcg\/mL. <jats:italic>M. intracellulare<\/jats:italic> and <jats:italic>M. kansasii<\/jats:italic> had lower resistance rates to omadacycline than the other five drugs. The severe resistance of SGM to tetracycline suggests that developing tetracycline\u2010class antibiotics needs to overcome existing resistance mechanisms.<\/jats:p>","DOI":"10.1111\/1440-1681.13777","type":"journal-article","created":{"date-parts":[[2023,4,22]],"date-time":"2023-04-22T09:24:19Z","timestamp":1682155459000},"page":"604-609","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["In vitro susceptibility testing of tetracycline\u2010class antibiotics against slowly growing non\u2010tuberculous mycobacteria"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2965-9901","authenticated-orcid":false,"given":"Anqi","family":"Li","sequence":"first","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Shanghai Pulmonary Hospital, School of Medicine Tongji University  Shanghai China"},{"name":"School of Medicine Tongji University  Shanghai 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