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However, its exact mechanism of action is still not fully understood. This study aimed to investigate the protective effect of moxibustion on cerebral ischemia\u2013reperfusion injury (CIRI) in rats. Middle cerebral artery occlusion\/reperfusion (MCAO\/R) was used to construct a CIRI rat model, all animals were randomly divided into four groups including sham operation group, MCAO\/R group (MCAO\/R), moxibustion therapy\u2009+\u2009MCAO\/R (Moxi) and ferrostatin\u20101\u2009+\u2009MCAO\/R (Fer\u20101) group. In the Moxi group, moxibustion treatment was initiated 24\u2009h after modeling, once a day for 30 mins each time for 7\u2009days. Moreover, the Fer\u20101 group received intraperitoneal injections of Fer\u20101 12\u2009h after modeling, once a day for a total of 7\u2009days. The results showed that moxibustion could reduce nerve function damage and neuronal death. Additionally, moxibustion could reduce the production of lipid peroxides such as lipid peroxide, malondialchehyche\u00a0and ACSL4 to regulate lipid metabolism, promote the production of glutathione and glutathione peroxidase 4 and reduce the expression of hepcidin by inhibiting the production of inflammatory factor interleukin\u20106, therefore, downregulating the expression of SLC40A1, reducing the iron level in the cerebral cortex, reducing the accumulation of reactive oxygen species and inhibiting ferroptosis. Based on our studies, it can be concluded that moxibustion has the ability to inhibit ferroptosis of nerve cells post CIRI and plays a protective role in the brain. This protective role can be attributed to the regulation of iron metabolism of nerve cells, reduction of iron deposition in the hippocampus and lowering the level of lipid peroxidation.<\/jats:p>","DOI":"10.1111\/1440-1681.13801","type":"journal-article","created":{"date-parts":[[2023,7,7]],"date-time":"2023-07-07T10:54:12Z","timestamp":1688727252000},"page":"779-788","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Moxibustion ameliorates cerebral ischemia\u2013reperfusion injury by regulating ferroptosis in rats"],"prefix":"10.1111","volume":"50","author":[{"given":"JingRuo","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Acupuncture Shanghai Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine  Shanghai China"},{"name":"Department of Acupuncture and Moxibustion Jiaxing Hospital of TCM, Zhejiang Chinese Medicine University  Jiaxing 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