{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T01:24:45Z","timestamp":1783128285370,"version":"3.54.6"},"reference-count":41,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,6,29]],"date-time":"2023-06-29T00:00:00Z","timestamp":1687996800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Exp Pharma Physio"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Skeletal muscles in animal models of Duchenne muscular dystrophy (DMD) are more susceptible to contraction\u2010induced functional loss, which is not related to fatigue. Valproic acid (VPA) reportedly improves serological and histological markers of damage in dystrophin\u2010deficient murine muscle. Here, we tested whether VPA would reduce the susceptibility to contraction\u2010induced functional loss in two murine DMD models. Adult female <jats:italic>mdx<\/jats:italic> (mild) and D2\u2010mdx (severe) DMD murine models were administered VPA (240\u2009mg\/kg) or saline for 7\u2009days. Some VPA\u2010treated <jats:italic>mdx<\/jats:italic> mice also performed voluntary running in a wheel, which is known to reduce the susceptibility to contraction\u2010induced functional loss; that is, isometric force drop following eccentric contractions. In situ muscle function was assessed before, during and after eccentric contractions. Muscle utrophin and desmin expression were also evaluated using immunoblotting. Interestingly, VPA reduced the isometric force drop following eccentric contractions in both murine models, without change in the relative eccentric maximal force and in the expression of utrophin and desmin. VPA for 7\u2009days combined with voluntary running had no additive effect compared to VPA alone. Furthermore, VPA reduced the absolute isometric maximal force before eccentric contractions in both murine models. The results of our study indicated that VPA in both murine DMD models reduced the susceptibility to contraction\u2010induced functional loss but increased muscle weakness.<\/jats:p>","DOI":"10.1111\/1440-1681.13804","type":"journal-article","created":{"date-parts":[[2023,6,29]],"date-time":"2023-06-29T08:19:26Z","timestamp":1688026766000},"page":"749-756","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Valproic acid reduces muscle susceptibility to contraction\u2010induced functional loss but increases weakness in two murine models of Duchenne muscular dystrophy"],"prefix":"10.1111","volume":"50","author":[{"given":"Dylan","family":"Moutachi","sequence":"first","affiliation":[{"name":"Centre de Recherche en Myologie, UMRS974, Inserm, Association Institut de Myologie Sorbonne Universit\u00e9  Paris 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