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In this study, we examined the effect of genetic BLT1 deletion (BLT1KO) on ovalbumin (OVA)\u2010induced allergic enteritis in mice to determine the pathogenic role of LTB4\/BLT1 in allergic enteritis, a gastrointestinal form of food allergy. Repeated oral OVA challenges after sensitization with OVA and aluminium potassium sulphate induced allergic enteritis, characterized by systemic allergic symptoms (scratching, immobility and swelling), diarrhoea, colonic oedema and colonic goblet cell hyperplasia, accompanied by increased colonic peroxidase activity, colonic inflammatory cytokine expression and increased serum OVA\u2010specific IgE levels. The severity of enteritis was significantly attenuated in BLT1KO mice compared with wild\u2010type (WT) mice, without an increase in serum OVA\u2010specific IgE levels. The accumulation of neutrophils, eosinophils, M2\u2010macrophages, dendritic cells, CD4+ T cells and mast cells was observed in the colonic mucosa of allergic enteritis, and such accumulation was significantly lower in BLT1KO mice than in WT mice. BLT1 expression was upregulated and colocalized mostly in neutrophils and partly in eosinophils and dendritic cells in the colonic mucosa of allergic enteritis. These findings indicate that BLT1 deficiency ameliorates OVA\u2010induced allergic enteritis in mice and that LTB4\/BLT1 contributes to neutrophil and eosinophil accumulation in the allergic colonic mucosa. Therefore, BLT1 is a promising drug target for treating food allergies.<\/jats:p>","DOI":"10.1111\/1440-1681.13808","type":"journal-article","created":{"date-parts":[[2023,7,5]],"date-time":"2023-07-05T23:19:56Z","timestamp":1688599196000},"page":"766-775","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Deficiency of leukotriene <scp>B4<\/scp> receptor type 1 ameliorates ovalbumin\u2010induced allergic enteritis in mice"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8280-7558","authenticated-orcid":false,"given":"Shinichi","family":"Kato","sequence":"first","affiliation":[{"name":"Division of Pathological Sciences, Laboratory of Pharmacology and Experimental Therapeutics Kyoto Pharmaceutical University  Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzuka","family":"Onishi","sequence":"additional","affiliation":[{"name":"Division of Pathological 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