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Autophagy is a mechanism that degrades intracellular components and compensates for energy deficiency, which is commonly observed in cardiomyocytes of failed hearts. Cardiomyocytes activated by doxorubicin (DOX) exhibit strong autophagy. This study aims to investigate the potential protective effect of ligustrazine and its derivative liguzinediol on regulating DOX\u2010induced cardiomyocyte apoptosis and explore the use of the embryonic rat heart\u2010derived myoblast cell line H9C2 for identifying novel treatments for HF. The results indicated that it has been demonstrated to reverse myocardial infarction remodelling in failed hearts by promoting autophagy in salvaged cardiomyocytes and anti\u2010apoptosis of cardiomyocytes in granulation tissue. Our study suggests that ligustrazine and liguzinediol can be a promising agents and autophagy is potential pathway in the management of HF.<\/jats:p>","DOI":"10.1111\/1440-1681.13811","type":"journal-article","created":{"date-parts":[[2023,8,14]],"date-time":"2023-08-14T04:40:10Z","timestamp":1691988010000},"page":"867-877","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Ligustrazine and liguzinediol protect against doxorubicin\u2010induced cardiomyocytes injury by inhibiting mitochondrial apoptosis and autophagy"],"prefix":"10.1111","volume":"50","author":[{"given":"Naqi","family":"Lian","sequence":"first","affiliation":[{"name":"School of Medicine and Holistic Integrative Medicine Nanjing University of Chinese Medicine  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Tong","sequence":"additional","affiliation":[{"name":"Xi'an International Medical Center Hospital  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