{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:59:53Z","timestamp":1787065193470,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,8,27]],"date-time":"2023-08-27T00:00:00Z","timestamp":1693094400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023A1515030139"],"award-info":[{"award-number":["2023A1515030139"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Exp Pharma Physio"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Artesunate (ART), an antimalarial drug with a multifunctional immunomodulatory effect, reduces psoriasis disease. ART can alleviate psoriasis\u2010like dermatitis in mice but has no effect on proinflammatory cytokines in the blood. Thus, we hypothesized that the skin might be the target tissue of ART during the treatment of psoriasis. The interleukin (IL)\u201023\/IL\u201017 axis has a key role in the pathogenesis of psoriasis. However, whether and how ART manipulates the IL\u201023 signal during psoriasis is unknown. This study found that IL\u201023 is highly expressed in the epidermis of psoriasis lesions and positively correlated with histological neutrophil infiltration and clinical psoriasis area and severity index (PASI)\u00a0scores. Furthermore, ART inhibits the migration and cell cycle, as well as tumor necrosis factor\u2010alpha (TNF\u2010\u03b1)\u2010induced IL\u201023 expression in HaCaT cells in a dose\u2010dependent manner, probably through interference with the nuclear factor kappa B (NF\u2010\u03baB) signalling pathway. Animal experiments in imiquimod (IMQ)\u2010induced psoriasis\u2010like mice model also suggested that ART dose\u2010dependently reduces IL\u201023 in the epidermis and ameliorates neutrophil infiltration. These findings thus provide further molecular evidence supporting ART as a promising drug for psoriasis in clinic.<\/jats:p>","DOI":"10.1111\/1440-1681.13816","type":"journal-article","created":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T02:07:09Z","timestamp":1693188429000},"page":"903-913","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Artesunate alleviates psoriasis\u2010like dermatitis by reducing interleukin\u201023 expression in tumor necrosis factor\u2010alpha\u2010induced\n                    <scp>HaCaT<\/scp>\n                    cells"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0864-8672","authenticated-orcid":false,"given":"Lixian","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Dermatology, Sun Yat\u2010sen Memorial Hospital Sun Yat\u2010sen University  Guangzhou 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