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It has been reported that circular RNA (circRNA) is a key regulatory factor of MF progression. In this study, we revealed that circ_0002295 and CXCR2 were elevated, and miR\u20101287 was reduced in MF patients. Knockdown of circ_0002295 effectively suppressed the proliferation, migration and MF progression. Circ_0002295 was the molecular sponge of miR\u201012878, and miR\u20101287 inhibitor reversed the biological functions of circ_0002295 on the myocardial fibrosis. CXCR2 was a target gene of miR\u20101287, and CXCR2 silencing relieved the impacts of miR\u20101287 inhibitor on cardiac myofibroblasts. Circ_0002295 promoted MF progression by regulating the miR\u20101287\/CXCR2 axis, providing a possible circRNA\u2010targeted therapy for MF.<\/jats:p>","DOI":"10.1111\/1440-1681.13819","type":"journal-article","created":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T09:04:51Z","timestamp":1694250291000},"page":"944-953","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Circ_0002295 facilitated myocardial fibrosis progression through the <scp>miR<\/scp>\u20101287\/<scp>CXCR2<\/scp> axis"],"prefix":"10.1111","volume":"50","author":[{"given":"Guo\u2010Bin","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Cardiology Fuzhou Second Hospital  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010Xu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Fuzhou Second Hospital  Fuzhou 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