{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T13:33:10Z","timestamp":1780320790262,"version":"3.54.1"},"reference-count":21,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T00:00:00Z","timestamp":1695859200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pericles.pericles-gcp.literatumonline.com"],"crossmark-restriction":true},"short-container-title":["Clin Exp Pharma Physio"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Myocardial ischemia\/reperfusion (I\/R) injury is the primary cause of heart damage in the treatment of myocardial infarction, and the imbalance of the energy metabolism in the pathogenesis of myocardial I\/R is one of the main triggers of cardiac dysfunction. Monocarboxylate transporter 4 (MCT4) is a key transporter of lactate, which plays a vital role in cellular metabolism. The present study investigated the role and underlying mechanism of MCT4 in myocardial I\/R injury. The results of this study showed that MCT4 was upregulated during oxygen\u2013glucose deprivation (OGD) and restored after reoxygenation in cardiomyocytes HL\u20101. Interestingly, the overexpression of MCT4 increased cell viability and decreased apoptosis of OGD\/R\u2010induced HL\u20101 cells. Furthermore, MCT4 boosted glucose uptake and lactate levels and promoted protein expression of glycolysis regulator LDHA, while also impeding oxidative phosphorylation (OXPHOS) regulators C\u2010MYC and NDUFB8 in OGD\/R\u2010induced HL\u20101 cells. A reduction in reactive oxygen species and oxidative stress markers malonaldehyde and superoxide dismutase was also observed within the OGD\/R stimulated HL\u20101 cells. Additionally, the in vivo exogenous application of MCT4 restored cardiac function, as demonstrated by the reduced infarct size and decreased myocardial apoptosis in I\/R rats. OXPHOS and oxidative stress declined, while glycolysis was activated when the I\/R mice were injected with AAV\u2010MCT4. Our findings indicate that MCT4 could exert a cardioprotective effect after myocardial I\/R injury by inducing OXPHOS\/glycolysis interconversion and inhibiting oxidative stress.<\/jats:p>","DOI":"10.1111\/1440-1681.13821","type":"journal-article","created":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T04:34:33Z","timestamp":1695962073000},"page":"954-963","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Monocarboxylate transporter 4 protects against myocardial ischemia\/reperfusion injury by inducing oxidative phosphorylation\/glycolysis interconversion and inhibiting oxidative stress"],"prefix":"10.1111","volume":"50","author":[{"given":"Qiao","family":"Pan","sequence":"first","affiliation":[{"name":"Department of Cardiology Xi'An International Medical Center Hospital  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobo","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Prevention and Control Center for Disease Control and Prevention of Southern Theatre Command  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingxia","family":"Yuan","sequence":"additional","affiliation":[{"name":"Intensive Care Unit Xi'An International Medical Center Hospital  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acvd.2020.04.007"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-019-0090-3"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2021.101960"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-54965-7"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/metabo10040132"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2016.12.013"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-022-01151-3"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2018.03.008"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2020.115302"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13018-023-03623-w"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.1587"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000354470"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)30677-8"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0119416"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2020.101454"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.4081\/oncol.2019.403"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2021013201"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-16966-3"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/4850328"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/2047487319870344"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6614009"}],"container-title":["Clinical and Experimental Pharmacology and Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1440-1681.13821","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T11:29:50Z","timestamp":1701257390000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1440-1681.13821"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,28]]},"references-count":21,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["10.1111\/1440-1681.13821"],"URL":"https:\/\/doi.org\/10.1111\/1440-1681.13821","archive":["Portico"],"relation":{},"ISSN":["0305-1870","1440-1681"],"issn-type":[{"value":"0305-1870","type":"print"},{"value":"1440-1681","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,28]]},"assertion":[{"value":"2023-04-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}