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The role of an expanded polyglutamine aggregate on neural progenitor cells is unknown. Here, we show that SCA3 patient\u2010specific induced neural progenitor cells (iNPCs) exhibit proliferative defects. Moreover, SCA3 iNPCs have reduced autophagic expression compared to control. Furthermore, although SCA3 iNPCs continue to proliferate, they do not survive subsequent passages compared to control iNPCs, indicating the likelihood that SCA3 iNPCs undergo rapid senescence. Exposure to interleukin\u20104 (IL\u20104), a type 2 cytokine produced by immune cells, resulted in an observed increase in expression of autophagic programs and a reduction in the proliferation defect observed in SCA3 iNPCs. Our results indicate a previously unobserved role of SCA3 disease ontology on the neural stem cell pool and a potential therapeutic strategy using IL\u20104 to ameliorate or delay disease pathology in the SCA3 neural progenitor cell population.<\/jats:p>","DOI":"10.1111\/1440-1681.13831","type":"journal-article","created":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T09:45:14Z","timestamp":1699350314000},"page":"30-39","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["<scp>IL\u20104\/STAT6<\/scp> axis observed to reverse proliferative defect in <scp>SCA3<\/scp> patient\u2010derived neural progenitor cells"],"prefix":"10.1111","volume":"51","author":[{"given":"Francis M.","family":"Chen","sequence":"first","affiliation":[{"name":"School of Life Sciences, Faculty of Science The Chinese University of Hong Kong  Hong Kong SAR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huixian","family":"Li","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Faculty of Science The Chinese University of Hong Kong  Hong Kong SAR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dittman Lai\u2010Shun","family":"Chung","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Faculty of Science The Chinese University of Hong Kong  Hong Kong SAR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angel T. 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