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Fifty\u2010four patients who underwent elective urological or pelvic surgery under general anaesthesia at Shanghai General Hospital were included in the present study; 51 patients were included for data analysis. Patients with normal PBF (&lt;25%) were given a single dose of rocuronium calculated based on total body weight (N\u2010TBW, control group). Patients with a higher PBF (\u226525%) were given a single dose of rocuronium calculated based on total body weight (H\u2010TBW). Patients with higher PBF and rocuronium were dosed based on fat\u2010free mass (H\u2010FFM). A train of four (TOF)\u2010Watch acceleromyography monitor was used to measure the effects of the rocuronium. H\u2010TBW (91.9\u2009\u00b1\u200928.8\u2009s) had significantly shorter onset time than N\u2010TBW and H\u2010FFM (<jats:italic>p<\/jats:italic>\u2009=\u20090.003). H\u2010TBW had significantly longer clinical duration time and pharmacological duration time than the other groups (<jats:italic>p<\/jats:italic>\u2009=\u20090.000 and 0.000, respectively); the TOF ratio<jats:sub>0.25\u20130.9<\/jats:sub> time was significantly different among the three groups (<jats:italic>p<\/jats:italic>\u2009=\u20090.005). There were no significant differences in the recovery time (<jats:italic>p<\/jats:italic>\u2009=\u20090.103) or recovery index (<jats:italic>p<\/jats:italic>\u2009=\u20090.159) among the three groups. The effects of rocuronium dosed based on FFM in patients with high PBFs are similar to those in normal patients. A single dose of rocuronium calculated based on TBW might shorten the onset time, prolong the clinical and pharmacological duration times, and prolong the recovery time.<\/jats:p>","DOI":"10.1111\/1440-1681.13836","type":"journal-article","created":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T00:03:50Z","timestamp":1704845030000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effects of a single dose of rocuronium in patients with different body fat percentages: A randomised controlled trial"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7543-0799","authenticated-orcid":false,"given":"Guanghui","family":"An","sequence":"first","affiliation":[{"name":"Department of Anesthesiology Shanghai General Hospital, Shanghai Jiaotong University Affiliated Shanghai General Hospital  Shanghai China"},{"name":"Department of Anesthesiology and Perioperative Medicine, Shanghai Key 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