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Four\u2010 and eight\u2010week CIH rat models were established, and Tempol (100\u2009mg\/kg\/d), was used as an oxidative stress inhibitor. This study included five groups: 4\u2010week CIH, 4\u2010week CIH\u2010Tempol, 8\u2010week CIH, 8\u2010week CIH\u2010Tempol and normal control (NC) groups. Fasting blood glucose and insulin levels were measured in the serum. The expression levels of 8\u2010hidroxy\u20102\u2010deoxyguanosine (8\u2010OHdG), tribbles homologue 3 (TRB3), c\u2010Jun N\u2010terminal kinase (JNK), phosphorylated JNK (p\u2010JNK), insulin receptor substrate\u20101 (IRS\u20101), phosphorylated IRS\u20101 (Ser307) (p\u2010IRS\u20101<jats:sup>ser307<\/jats:sup>), protein kinase B (AKT), phosphorylated AKT (Ser473) (p\u2010AKT<jats:sup>ser473<\/jats:sup>), B cell lymphoma protein\u20102 (Bcl\u20102), cleaved\u2010caspase\u20103 (Cl\u2010caspase\u20103), and the islet cell apoptosis were detected in the pancreas. CIH induced oxidative stress in the pancreas. Compared with that in the NC group and CIH\u2010Tempol groups individually, the homeostasis model assessment of insulin resistance (HOMA\u2010IR) and apoptosis of islet cells was increased in the CIH groups. CIH\u2010induced oxidative stress increased the expression of p\u2010IRS\u20101<jats:sup>Ser307<\/jats:sup> and decreased the expression of p\u2010AKT<jats:sup>Ser473<\/jats:sup>. The expression levels of TRB3 and p\u2010JNK were higher in the CIH groups than in both the CIH\u2010Tempol and NC groups. Meanwhile, the expressions of Cl\u2010caspase\u20103 and Bcl\u20102 were upregulated and downregulated, respectively, in the CIH groups. Hence, the present study demonstrated that CIH\u2010induced oxidative stress might not only induce insulin resistance but also islet cell apoptosis in the pancreas through TRB3 and p\u2010JNK.<\/jats:p>","DOI":"10.1111\/1440-1681.13843","type":"journal-article","created":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T00:39:45Z","timestamp":1706488785000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Chronic intermittent hypoxia\u2010induced oxidative stress activates <scp>TRB3<\/scp> and <scp>phosphorylated JNK<\/scp> to mediate insulin resistance and cell apoptosis in the pancreas"],"prefix":"10.1111","volume":"51","author":[{"given":"Shan","family":"Zeng","sequence":"first","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine The Second Affiliated Hospital of Kunming Medical University  Kunming 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