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Bloodstream infection (BSI) is a leading cause of treatment\u2010related mortality in ALL patients. However, the epidemiology and risk factors for mortality from BSIs in AYA patients remain unclear. In this study, we analysed these aspects in AYAs patients and compared similarities and differences with children (&lt;15\u2009years old) and older adults (&gt;39\u2009years old). We analysed the pathogenic epidemiology, antibiotic resistance and BSI risk factors of 73 children, 180 AYAs, and 110 older adults with ALL in three comprehensive hospitals from January 2010 to August 2021. The data on BSIs in AYAs were compared to that of the other two groups. In this study, the epidemiology of BSIs in AYAs was similar to that of older adult patients. Concerning clinical characteristics, most AYAs and older adults with BSIs were in a relapsed or uncontrolled state (34.5% vs. 35.4%, p\u2009=\u20090.861). In terms of pathogen distribution, Gram\u2010negative bacteria (GNB) were the most common causative pathogens in AYAs and older adult groups. Extended\u2010spectrum beta\u2010lactamase (ESBL)\u2010producing bacteria were more commonly found in AYAs than in children (32.8% vs. 16.4%, p\u2009=\u20090.09). Regarding risk factors, the length of hospitalization (&gt;14\u2009days) and renal inadequacy (creatinine\u2009\u2265\u2009177\u2009\u03bcmol\/L) were influencing factors for 30\u2010day mortality in AYAs patients with BSIs. In our study, AYA patients with BSIs showed clinical characteristics and pathogen distributions similar to those of older adult patients but quite different from those of children.<\/jats:p>","DOI":"10.1111\/1440-1681.13850","type":"journal-article","created":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T23:26:10Z","timestamp":1709853970000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Epidemiology and risk factors of bloodstream infections among adolescents and young adults with acute lymphoblastic leukaemia: An 11\u2010year retrospective cohort study"],"prefix":"10.1111","volume":"51","author":[{"given":"Longlong","family":"Xue","sequence":"first","affiliation":[{"name":"Department of Hematology The Third Xiangya Hospital, Central South University  Changsha People's Republic of 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