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Therefore, in ovine CPB, we assessed regional cerebral oxygen saturation (rSO<jats:sub>2<\/jats:sub>) by near\u2010infrared spectroscopy and renal cortical and medullary tissue oxygen tension (PO<jats:sub>2<\/jats:sub>), and, in some protocols, brain tissue PO<jats:sub>2<\/jats:sub>, by phosphorescence lifetime oximetry. During CPB, rSO<jats:sub>2<\/jats:sub> correlated with mixed venous SO<jats:sub>2<\/jats:sub> (r\u2009=\u20090.78) and brain tissue PO<jats:sub>2<\/jats:sub> (r\u2009=\u20090.49) when arterial PO<jats:sub>2<\/jats:sub> was varied. During the first 30\u2009min of CPB, brain tissue PO<jats:sub>2<\/jats:sub>, rSO<jats:sub>2<\/jats:sub> and renal cortical tissue PO<jats:sub>2<\/jats:sub> did not fall, but renal medullary tissue PO<jats:sub>2<\/jats:sub> did. Nevertheless, compared with stable anaesthesia, during stable CPB, rSO<jats:sub>2<\/jats:sub> (66.8 decreasing to 61.3%) and both renal cortical (90.8 decreasing to 43.5\u2009mm Hg) and medullary (44.3 decreasing to 19.2\u2009mm Hg) tissue PO<jats:sub>2<\/jats:sub> were lower. Both rSO<jats:sub>2<\/jats:sub> and renal PO<jats:sub>2<\/jats:sub> increased when pump flow was increased from 60 to 100\u2009mL\u2009kg<jats:sup>\u22121<\/jats:sup>\u2009min<jats:sup>\u22121<\/jats:sup> at a target arterial pressure of 70\u2009mm Hg. They also both increased when pump flow and arterial pressure were increased simultaneously. Neither was significantly altered by partially pulsatile flow. The vasopressor, metaraminol, dose\u2010dependently decreased rSO<jats:sub>2<\/jats:sub>, but increased renal cortical and medullary PO<jats:sub>2<\/jats:sub>. Increasing blood haemoglobin concentration increased rSO<jats:sub>2<\/jats:sub>, but not renal PO<jats:sub>2<\/jats:sub>. We conclude that both the brain and kidney are susceptible to hypoxia during CPB, which can be alleviated by increasing pump flow, even without increasing arterial pressure. However, increasing blood haemoglobin concentration increases brain, but not kidney oxygenation, whereas vasopressor support with metaraminol increases kidney, but not brain oxygenation.<\/jats:p>","DOI":"10.1111\/1440-1681.13852","type":"journal-article","created":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T23:26:16Z","timestamp":1709853976000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Differential responses of cerebral and renal oxygenation to altered perfusion conditions during experimental cardiopulmonary bypass in sheep"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9241-0757","authenticated-orcid":false,"given":"Roger G.","family":"Evans","sequence":"first","affiliation":[{"name":"Cardiovascular Disease Program, Biomedicine Discovery Institute and Department of Physiology Monash University  Melbourne Victoria Australia"},{"name":"Pre\u2010clinical Critical Care Unit, Florey Institute of Neuroscience and Mental Health University of Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew D.","family":"Cochrane","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Monash Health and Department of Surgery (School of Clinical Sciences at Monash Health) Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally G.","family":"Hood","sequence":"additional","affiliation":[{"name":"Pre\u2010clinical Critical Care Unit, Florey Institute of Neuroscience and Mental Health University of Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Marino","sequence":"additional","affiliation":[{"name":"Cellsaving and Perfusion Resources  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoya","family":"Iguchi","sequence":"additional","affiliation":[{"name":"Pre\u2010clinical Critical Care Unit, Florey Institute of Neuroscience and Mental Health University of Melbourne  Melbourne Victoria Australia"},{"name":"Department of Anesthesiology and Intensive Care Medicine, Graduate School of Medicine Osaka University  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rinaldo","family":"Bellomo","sequence":"additional","affiliation":[{"name":"Cardiovascular Disease Program, Biomedicine Discovery Institute and Department of Physiology Monash University  Melbourne Victoria Australia"},{"name":"Department of Intensive Care, Austin Health  Heidelberg Victoria Australia"},{"name":"Department of Critical Care, Melbourne Medical School University of Melbourne  Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter R.","family":"McCall","sequence":"additional","affiliation":[{"name":"Department of Critical Care, Melbourne Medical School University of Melbourne  Victoria Australia"},{"name":"Department of Anaesthesia, Austin Health  Heidelberg Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuki","family":"Okazaki","sequence":"additional","affiliation":[{"name":"Pre\u2010clinical Critical Care Unit, Florey Institute of Neuroscience and Mental Health University of Melbourne  Melbourne Victoria Australia"},{"name":"Department of Anesthesiology and Resuscitology Okayama University  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alemayehu H.","family":"Jufar","sequence":"additional","affiliation":[{"name":"Cardiovascular Disease Program, Biomedicine Discovery Institute and Department of Physiology Monash University  Melbourne Victoria Australia"},{"name":"Pre\u2010clinical Critical Care Unit, Florey Institute of Neuroscience and Mental Health University of Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lachlan F.","family":"Miles","sequence":"additional","affiliation":[{"name":"Pre\u2010clinical Critical Care Unit, Florey Institute of Neuroscience and Mental Health University of Melbourne  Melbourne Victoria Australia"},{"name":"Department of Critical Care, Melbourne Medical School University of Melbourne  Victoria Australia"},{"name":"Department of Anaesthesia, Austin Health  Heidelberg Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taku","family":"Furukawa","sequence":"additional","affiliation":[{"name":"Pre\u2010clinical Critical Care Unit, Florey Institute of Neuroscience and Mental Health University of Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Connie P. 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