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It has been shown that cocaine and amphetamine\u2010regulated transcript (CART) can ameliorate cerebral ischemia\u2013reperfusion (I\/R) injury, but the effect of CART on MIRI has not been studied yet. Here, we revealed that CART protected the heart during I\/R process by inhibiting apoptosis and excessive autophagy, indicating that CART would be a potential drug candidate for the treatment of MIRI. Further analysis showed that CART upregulated the activation of phospho\u2010AKT, leading to downregulation of lactate dehydrogenase (LDH) release, apoptosis, oxidative stress and excessive autophagy after I\/R, which was inhibited by PI3K inhibitor, LY294002. Collectively, CART attenuated MIRI through inhibition of cardiomyocytes apoptosis and excessive autophagy, and the protective effect was dependent on PI3K\/AKT signalling pathway.<\/jats:p>","DOI":"10.1111\/1440-1681.13904","type":"journal-article","created":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T00:30:31Z","timestamp":1719189031000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Cocaine and amphetamine\u2010regulated transcript improves myocardial ischemia\u2013reperfusion injury through <scp>PI3K<\/scp>\/<scp>AKT<\/scp> signalling pathway"],"prefix":"10.1111","volume":"51","author":[{"given":"Yachen","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Molecular Pharmacology, School of Medicine Nankai University  Tianjin China"},{"name":"Tianjin Eye Hospital, Tianjin Key Laboratory of Ophthalmology and Visual Science Tianjin Eye Institute  Tianjin 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