{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T09:37:33Z","timestamp":1766050653035,"version":"3.41.2"},"reference-count":38,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T00:00:00Z","timestamp":1720051200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Exp Pharma Physio"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In this study, we wanted to investigate the effectiveness of combining disease\u2010modifying anti\u2010rheumatic drugs (DMARD) with hyperbaric oxygen therapy (HBOT) in reducing inflammation in a rheumatoid arthritis (RA) model using rats. We divided 56 male Sprague\u2013Dawley rats into seven groups and induced RA using complete Freund's adjuvant. Some groups received HBOT, whereas others were given etanercept or leflunomide. We started the treatment on the 10th day after inducing RA and continued it for 18\u2009days. To evaluate the effectiveness of the treatments, we measured paw swelling and used X\u2010rays to examine the joints before and after the treatment. We also analysed the levels of two inflammatory markers, tumour necrosis factor (TNF)\u2010\u03b1 and interleukin (IL)\u20101\u03b2, using an enzyme\u2010linked immunosorbent assay. Additionally, we conducted histological analysis and assessed the expressions of anti\u2010IL\u20101\u03b2 and anti\u2010TNF\u2010\u03b1 antibodies. All the treatment groups showed a significant decrease in arthritis scores, paw swelling and levels of TNF\u2010\u03b1 and IL\u20101\u03b2. The X\u2010ray images revealed improvements in joint structure, and the histopathological analysis showed reduced inflammation and collagen abnormalities. Combining DMARD with HBOT had similar effects to individual therapies, suggesting a cost\u2010effective and potentially safer approach for improving outcomes in rats with RA.<\/jats:p>","DOI":"10.1111\/1440-1681.13906","type":"journal-article","created":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T04:20:55Z","timestamp":1720153255000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Comparison of disease\u2010modifying anti\u2010rheumatic drugs and hyperbaric oxygen therapy in the experimental model of rheumatoid arthritis in rats"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3829-8888","authenticated-orcid":false,"given":"Mohamad","family":"Hallak","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Institute of Health Sciences Erciyes University  Kayseri 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