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However, its specific regulatory effects in ischaemic stroke progression remain unclear. In this study, we established a middle cerebral artery occlusion (MCAO) rat model. Treatment with PHI (50 or 100\u2009mg\/kg) significantly reduced cerebral infarction in MCAO rats. PHI treatment also mitigated the increased inflammatory response observed in these rats. Additionally, PHI suppressed microglial activation by reducing iNOS expression, a marker of M1\u2010type polarization of microglia, and attenuated increased brain tissue apoptosis in MCAO rats. Furthermore, PHI's anti\u2010inflammatory effects in MCAO rats were abrogated upon co\u2010administration with GW9662, a peroxisome proliferator\u2010activated receptor \u03b3 (PPAR\u03b3) inhibitor. In summary, PHI attenuated microglial activation and apoptosis in cerebral ischaemia\u2013reperfusion injury through PPAR\u03b3 activation, suggesting its potential as a therapeutic agent for mitigating cerebral ischaemia\u2013reperfusion injury.<\/jats:p>","DOI":"10.1111\/1440-1681.13917","type":"journal-article","created":{"date-parts":[[2024,9,17]],"date-time":"2024-09-17T19:09:34Z","timestamp":1726600174000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Phillygenin attenuates cell apoptosis and microglia activation in cerebral ischaemia\u2013reperfusion rats through activation of peroxisome proliferator\u2010activated receptor \u03b3"],"prefix":"10.1111","volume":"51","author":[{"given":"Chaojun","family":"Yan","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, The People's Hospital of Danyang Affiliated Danyang Hospital of Nantong University  Danyang 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