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Given the limited research on the effects of combined exercise on an ageing liver, this study aimed to evaluate its impact on liver metabolism, circadian rhythms and mitochondrial function in senescence\u2010accelerated mouse\u2010prone 8 (SAMP8) and senescence\u2010accelerated mouse\u2010resistant 1 (SAMR1) mice. Histological, reverse transcription quantitative polymerase chain reaction (RT\u2010qPCR) and immunoblotting analyses were conducted, supplemented by transcriptomic data sets and AML12 hepatocyte studies. Sedentary SAMP8 mice exhibited decreased muscle strength, reduced mitochondrial complex I levels and increased lipid droplet accumulation. In contrast, combined exercise mitigated muscle strength loss, upregulated proteins involved in mitochondrial complexes (CIII, CIV, CV) and increased <jats:italic>Bmal1<\/jats:italic> messenger RNA (mRNA) expression in the liver. These molecular adaptations are associated with healthier liver phenotypes and may influence metabolic function and cellular longevity. Notably, elevated lipid content in aged mice was reduced post\u2010exercise, indicating liver benefits even after a relatively short intervention. The combined exercise regimen did not improve aerobic capacity, likely due to the low volume and brief duration of running. Moreover, no significant effects were observed in SAMR1 mice, possibly because the training intensity was insufficient for younger, healthier animals. These findings underscore the potential of combined strength and endurance exercise to attenuate age\u2010related liver dysfunction, particularly in ageing populations.<\/jats:p>","DOI":"10.1111\/1440-1681.70001","type":"journal-article","created":{"date-parts":[[2024,10,31]],"date-time":"2024-10-31T01:49:27Z","timestamp":1730339367000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Short\u2010term exercise counteracts accelerated ageing impacts on physical performance and liver health in mice"],"prefix":"10.1111","volume":"51","author":[{"given":"Ana P.","family":"Pinto","sequence":"first","affiliation":[{"name":"School of Physical Education and Sport of Ribeir\u00e3o Preto University of S\u00e3o Paulo (USP)  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vitor R.","family":"Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"School of Physical Education and Sport of Ribeir\u00e3o Preto University of S\u00e3o Paulo (USP)  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Eduarda A.","family":"Tavares","sequence":"additional","affiliation":[{"name":"Department of Physical Education State University of S\u00e3o Paulo (UNESP)  S\u00e3o Paulo Brazil"},{"name":"Multicentric Program of Postgraduate in Physiological Sciences, School of Dentistry of Ara\u00e7atuba S\u00e3o Paulo State University (UNESP)  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivo V. de Sousa","family":"Neto","sequence":"additional","affiliation":[{"name":"School of Physical Education and Sport of Ribeir\u00e3o Preto University of S\u00e3o Paulo (USP)  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathas R.","family":"dos Santos","sequence":"additional","affiliation":[{"name":"Department of Biomolecular Sciences, School of Pharmaceutical Sciences of Ribeirao Preto University of S\u00e3o Paulo\u2010FCFRP USP  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilherme S.","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Ribeir\u00e3o Preto Medical School University of S\u00e3o Paulo (USP)  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruither O. Gomes","family":"Carolino","sequence":"additional","affiliation":[{"name":"School of Physical Education and Sport of Ribeir\u00e3o Preto University of S\u00e3o Paulo (USP)  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciane C.","family":"Alberici","sequence":"additional","affiliation":[{"name":"Department of Biomolecular Sciences, School of Pharmaceutical Sciences of Ribeirao Preto University of S\u00e3o Paulo\u2010FCFRP USP  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando M.","family":"Simabuco","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Biology of Exercise (LaBMEx), School of Applied Sciences University of Campinas (UNICAMP)  S\u00e3o Paulo Brazil"},{"name":"Department of Biochemistry Federal University of S\u00e3o Paulo (UNIFESP)  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovana R.","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Department of Physical Education State University of S\u00e3o Paulo (UNESP)  S\u00e3o Paulo Brazil"},{"name":"Multicentric Program of Postgraduate in Physiological Sciences, School of Dentistry of Ara\u00e7atuba S\u00e3o Paulo State University (UNESP)  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 R.","family":"Pauli","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Biology of Exercise (LaBMEx), School of Applied Sciences University of Campinas (UNICAMP)  S\u00e3o Paulo Brazil"},{"name":"Nutrigenomics and Lipids Research Center, CELN, School of Applied Sciences UNICAMP  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leandro P.","family":"de Moura","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Biology of Exercise (LaBMEx), School of Applied Sciences University of Campinas (UNICAMP)  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennys E.","family":"Cintra","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Biology of Exercise (LaBMEx), School of Applied Sciences University of Campinas (UNICAMP)  S\u00e3o Paulo Brazil"},{"name":"Nutrigenomics and Lipids Research Center, CELN, School of Applied Sciences UNICAMP  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo R.","family":"Ropelle","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Biology of Exercise (LaBMEx), School of Applied Sciences University of Campinas (UNICAMP)  S\u00e3o Paulo Brazil"},{"name":"Nutrigenomics and Lipids Research Center, CELN, School of Applied Sciences UNICAMP  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen C.","family":"Freitas","sequence":"additional","affiliation":[{"name":"School of Physical Education and Sport of Ribeir\u00e3o Preto University of S\u00e3o Paulo (USP)  S\u00e3o Paulo Brazil"},{"name":"Department of Health Sciences, Ribeir\u00e3o Preto Medical School University of S\u00e3o Paulo (USP)  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donato A.","family":"Rivas","sequence":"additional","affiliation":[{"name":"Center for Exercise Medicine Research, Fralin Biomedical Research Institute Virginia Tech Carilion  Roanoke Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9679-8357","authenticated-orcid":false,"given":"Adelino S. 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