{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T23:55:12Z","timestamp":1787874912475,"version":"build-2784847793"},"reference-count":33,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T00:00:00Z","timestamp":1731024000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Exp Pharma Physio"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Ulcerative colitis (UC) is a condition characterized by inflammation and ulcer formation in the colon and rectum due to genetic and environmental factors. It is a common condition, with a global prevalence rate exceeding 0.3%. Current treatments have limited efficacy and can cause unwanted side effects, leading to a high recurrence rate and reduced quality of life for patients. This study suggests that <jats:italic>Bacillus clausii<\/jats:italic> has a beneficial role in reducing intestinal inflammation and relieving colitis symptoms in mice. The study aimed to examine <jats:italic>B. clausii<\/jats:italic>'s potential to reduce the progression and pathogenesis of dextran sulphate sodium (DSS)\u2013induced UC. <jats:italic>Bacillus clausii<\/jats:italic> was administered to mice as a pre\u2010treatment, post\u2010treatment and adjunct treatment with sulfasalazine for 14\u2009days. The study found that <jats:italic>B. clausii<\/jats:italic> effectively reduced the severity of colitis in mice when used preventatively. Administering <jats:italic>B. clausii<\/jats:italic> after the onset of colitis also effectively alleviated symptoms. Combining <jats:italic>B. clausii<\/jats:italic> with standard sulfasalazine as adjunct therapy was more effective in reducing intestinal inflammation than using a single therapy alone. <jats:italic>B. clausii<\/jats:italic> has shown the potential to prevent colon damage and decrease the likelihood and severity of the disease. Immunohistochemistry results revealed a decrease in the expression of pro\u2010inflammatory cytokines such as IL\u20101\u03b2, TNF\u2010\u03b1 and NFkB in colon tissue. Additionally, mice that received <jats:italic>B. clausii<\/jats:italic> showed a significant increase in anti\u2010oxidant levels and improved haematological markers. In conclusion, it must be emphasized that <jats:italic>B. clausii<\/jats:italic> possesses the potential to alleviate the symptoms of UC.<\/jats:p>","DOI":"10.1111\/1440-1681.70004","type":"journal-article","created":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T10:20:22Z","timestamp":1731061222000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Effect of <i>Bacillus clausii<\/i> in attenuating symptoms of <scp>DSS<\/scp>\u2010induced ulcerative colitis by modulating <scp>NFkB<\/scp> pathway and oxidative stress in mice"],"prefix":"10.1111","volume":"51","author":[{"given":"Syeda Rida","family":"Zainab","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Faculty of Biological Sciences Quaid\u2010i\u2010Azam University  Islamabad Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jehan Zeb","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Biological Sciences Quaid\u2010i\u2010Azam University  Islamabad Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mujeeb Ur","family":"Rehman","sequence":"additional","affiliation":[{"name":"Department of Pharmacy CECOS University of IT and Emerging Sciences  Peshawar Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fawad Ali","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology College of Pharmacy Prince Sattam Bin Abdulaziz University  Al\u2010Kharj Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Khalid","family":"Tipu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Biological Sciences Quaid\u2010i\u2010Azam University  Islamabad Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,8]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2017.6524"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2022-065186"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.11.7966"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2014.66"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-022-03215-5"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12866-019-1610-8"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)32448-0"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12038-019-9926-y"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2024.1355542"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1099\/jmmcr.0.004036"},{"issue":"9","key":"e_1_2_11_12_1","first-page":"1344","article-title":"A randomized double\u2010blind placebo\u2010controlled clinical trial on efficacy and safety of association of simethicone and Bacillus coagulans (Colinox\u00ae) in patients with irritable bowel syndrome","volume":"18","author":"Urgesi R","year":"2014","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2014.0181"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.3945\/jn.114.199802"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40794-022-00166-6"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu16071055"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.840245"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2672.1989.tb05105.x"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fm.2010.03.007"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.551449"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20736"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.865982"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/9416794"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.25122\/jml-2018-0075"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-022-02285-0"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i19.5985"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mcg.0000128925.06662.69"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02815-15"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2007.41"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-019-10259-6"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.5625\/lar.2012.28.2.77"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1177\/0748233711420472"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-016-0376-5"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2009.12.013"}],"container-title":["Clinical and Experimental Pharmacology and Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1440-1681.70004","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T06:06:33Z","timestamp":1731305193000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1440-1681.70004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,8]]},"references-count":33,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.1111\/1440-1681.70004"],"URL":"https:\/\/doi.org\/10.1111\/1440-1681.70004","archive":["Portico"],"relation":{},"ISSN":["0305-1870","1440-1681"],"issn-type":[{"value":"0305-1870","type":"print"},{"value":"1440-1681","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,8]]},"assertion":[{"value":"2024-08-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70004"}}