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We established a HSPN rat model in a high\u2010altitude hypoxic (HH) environment. Renal tissue lesions were observed by haematoxylin and Eosin (H&amp;E) staining and terminal deoxynucleotidyl transferase\u2010mediated dUTP nick end labelling (TUNEL), CD20\u2010postive B cells and CD68\u2010postive macrophage cells were detected by immunohistochemistry, T\u2010cell activation was detected by flow cytometry and toll\u2010like receptor 4 (TLR4)\/nuclear factor\u2010kappa B (NF\u2010\u03baB)\/NOD\u2010like receptor thermal protein domain associated protein 3 (NLRP3) signalling was detected by western blot. TAK\u2010242 inhibited the expression of TLR4\/NF\u2010\u03baB\/NLRP3 signalling related\u2010proteins, decreased the levels of 24\u2009h urinary protein, serum creatinine, circular immune complex (CIC) and kidney immunoglobulin A (IgA), and improved renal histopathological damage in HH\u2010HSPN rats. Furthermore, TAK\u2010242 attenuated the infiltration of CD20 and CD68 into the kidney and increased the percentage of CD3+, CD4+ and CD4+\/CD8+ cells in the blood of HH\u2010HSPN rats. The study revealed that suppressing TLR4\/NF\u2010\u03baB\/NLRP3 signalling improved renal function and histopathological damage, and this improvement was related to inhibiting the inflammatory response and enhancing immune competence.<\/jats:p>","DOI":"10.1111\/1440-1681.70008","type":"journal-article","created":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T12:06:43Z","timestamp":1732104403000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["<scp>TLR4<\/scp> Inhibitor <scp>TAK<\/scp>\u2010242 Protected Henoch\u2013Schonlein Purpura Nephritis in Rats by Regulating Inflammatory Response and Immune Competence via <scp>NF<\/scp>\u2010 <scp>\u03baB<\/scp>\/<scp>NLRP3<\/scp> Signalling"],"prefix":"10.1111","volume":"52","author":[{"given":"Yirong","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Nephrology First People's Hospital of Xining City  Xining 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