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Oroxin B is a natural flavonoid glycoside with a variety of biological activities, including anti\u2010inflammatory and autophagy\u2010promoting effects, and has therapeutic benefits for a variety of diseases. The aim of this study was to investigate the potential therapeutic role of Oroxin B in the development of \u03b21\u2010AAb\u2010induced atrial fibrillation and to elucidate the underlying mechanisms involved. We established a rat model of \u03b21\u2010AAb\u2010induced atrial fibrillation via active immunisation. The first stage was divided into three groups: the control group, the \u03b21\u2010AAb group and the \u03b21\u2010AAb\u2009+\u2009bisoprolol group. The second stage was divided into three groups: the control group, the \u03b21\u2010AAb group and the \u03b21\u2010AAb\u2009+\u2009Oroxin B group. Serum levels of \u03b21\u2010AAbs, atrial tissue levels of cyclic monophosphate (cAMP), atrial electrophysiological parameters, cardiac structure and function, mitochondrial structure, autophagy levels, cardiomyocyte apoptosis and myocardial fibrosis were examined. The results showed that bisoprolol, a \u03b21\u2010blocker, improved \u03b21\u2010AAb\u2010induced atrial electrical remodelling, reduced atrial collagen deposition, ameliorated the increase in LAD and regulated the balance of autophagy and apoptosis in atrial myocytes through the PTEN\/AKT\/mTOR signalling pathway. Oroxin B, a PTEN agonist, can improve the impairment of autophagy homeostasis and apoptosis in atrial tissue by activating the PTEN\/AKT\/mTOR signalling pathway, thereby improving atrial structure and electrical remodelling. Moreover, Oroxin B may play a therapeutic role in \u03b21AAb\u2010induced atrial fibrillation. In conclusion, our results demonstrate the potential therapeutic role of Oroxin B in \u03b21AAb\u2010induced atrial fibrillation and the underlying mechanisms, suggesting that Oroxin B may be an effective antiarrhythmic medication.<\/jats:p>","DOI":"10.1111\/1440-1681.70011","type":"journal-article","created":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T05:40:15Z","timestamp":1733722815000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Oroxin B Resembles Bisoprolol in Attenuating Beta1\u2010Adrenergic Receptor Autoantibody\u2010Induced Atrial Remodelling via the <scp>PTEN<\/scp>\/<scp>AKT<\/scp>\/<scp>mTOR<\/scp> Signalling Pathway"],"prefix":"10.1111","volume":"52","author":[{"given":"Na","family":"Yang","sequence":"first","affiliation":[{"name":"Xinjiang Key Laboratory of Cardiac Electrophysiology and Remodelling The First Affiliated Hospital of Xinjiang Medical University  Urumqi China"},{"name":"Department of Pacing and Electrophysiology The First Affiliated Hospital of Xinjiang Medical University  Urumqi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaxin","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Cardiology, the Third People's Hospital of Chengdu, Affiliated Hospital of Southwest Jiaotong University Chengdu Cardiovascular Disease Research Institute  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linqiang","family":"Xi","sequence":"additional","affiliation":[{"name":"Xinjiang Key Laboratory of Cardiac Electrophysiology and Remodelling The First Affiliated Hospital of Xinjiang Medical University  Urumqi China"},{"name":"Department of Pacing and Electrophysiology The First Affiliated Hospital of Xinjiang Medical University  Urumqi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Zhang","sequence":"additional","affiliation":[{"name":"Xinjiang Key Laboratory of Cardiac Electrophysiology and Remodelling The First Affiliated Hospital of Xinjiang Medical University  Urumqi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanmei","family":"Lu","sequence":"additional","affiliation":[{"name":"Xinjiang Key Laboratory of Cardiac Electrophysiology and Remodelling The First Affiliated Hospital of Xinjiang Medical University  Urumqi China"},{"name":"Department of Pacing and Electrophysiology The First Affiliated Hospital of Xinjiang Medical University  Urumqi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianhui","family":"Wang","sequence":"additional","affiliation":[{"name":"Xinjiang Key Laboratory of Cardiac Electrophysiology and Remodelling The First Affiliated Hospital of Xinjiang Medical University  Urumqi China"},{"name":"Department of Pacing and Electrophysiology The First Affiliated Hospital of Xinjiang Medical University  Urumqi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaru","family":"Cao","sequence":"additional","affiliation":[{"name":"Xinjiang Key Laboratory of Cardiac Electrophysiology and Remodelling The First Affiliated Hospital of Xinjiang Medical University  Urumqi China"},{"name":"Department of Pacing and Electrophysiology The First Affiliated Hospital of Xinjiang Medical University  Urumqi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Song","sequence":"additional","affiliation":[{"name":"Xinjiang Key Laboratory of Cardiac Electrophysiology and Remodelling The First Affiliated Hospital of Xinjiang Medical University  Urumqi China"},{"name":"Department of Pacing and Electrophysiology The First Affiliated Hospital of Xinjiang Medical University  Urumqi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baopeng","family":"Tang","sequence":"additional","affiliation":[{"name":"Xinjiang Key Laboratory of Cardiac Electrophysiology and Remodelling The First Affiliated Hospital of Xinjiang Medical University  Urumqi China"},{"name":"Department of Pacing and Electrophysiology The First Affiliated Hospital of Xinjiang Medical University  Urumqi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luxiang","family":"Shang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, the First Affiliated Hospital of Shandong First Medical University &amp; 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