{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:25:28Z","timestamp":1753878328663,"version":"3.41.2"},"reference-count":6,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T00:00:00Z","timestamp":1747008000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Exp Pharma Physio"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>The study by An et\u00a0al. provides valuable insights into rocuronium pharmacodynamics in patients with high body fat percentages (PBF). However, the lack of normalisation for acceleromyographic train\u2010of\u2010four (TOF) ratios raises concerns about the validity of endpoints. Due to the acceleromygraph's inherent \u201cinverse fade\u201d artefact, non\u2010normalised TOF ratios may mask clinically significant residual paralysis. For example, a reported TOF of 0.9 could correspond to a true ratio of 0.75 (assuming a baseline of 1.2), overestimating recovery. This methodological gap weakens the study's conclusion on fat\u2010free mass\u2010based dosing advantages in high\u2010PBF patients. Future studies should adopt TOF normalisation or electromyography (EMG)\u2010based monitoring to improve accuracy and patient safety. Addressing this limitation would strengthen the clinical applicability of individualised neuromuscular blocking strategies.<\/jats:p>","DOI":"10.1111\/1440-1681.70047","type":"journal-article","created":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T04:10:23Z","timestamp":1747109423000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Comment About Methodological Limitations on the Study by <scp>An et\u00a0al.<\/scp>"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2990-3751","authenticated-orcid":false,"given":"B\u00fcy\u00fckcavlak","family":"Mustafa","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Reanimation University of Health Sciences, Konya City Hospital  Konya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,5,12]]},"reference":[{"key":"e_1_2_1_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/1440-1681.13836"},{"key":"e_1_2_1_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aei273"},{"key":"e_1_2_1_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000005054"},{"key":"e_1_2_1_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000005051"},{"key":"e_1_2_1_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000003896"},{"key":"e_1_2_1_6_7_1","doi-asserted-by":"publisher","DOI":"10.4103\/sja.sja_326_22"}],"container-title":["Clinical and Experimental Pharmacology and Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1440-1681.70047","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T23:25:08Z","timestamp":1749770708000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1440-1681.70047"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,12]]},"references-count":6,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1111\/1440-1681.70047"],"URL":"https:\/\/doi.org\/10.1111\/1440-1681.70047","archive":["Portico"],"relation":{},"ISSN":["0305-1870","1440-1681"],"issn-type":[{"type":"print","value":"0305-1870"},{"type":"electronic","value":"1440-1681"}],"subject":[],"published":{"date-parts":[[2025,5,12]]},"assertion":[{"value":"2025-04-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70047"}}