{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T05:50:55Z","timestamp":1784872255445,"version":"3.55.0"},"reference-count":53,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T00:00:00Z","timestamp":1759881600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100016067","name":"Shaanxi Administration of Traditional Chinese Medicine","doi-asserted-by":"publisher","award":["2021\u201002\u2010ZZ\u2010012"],"award-info":[{"award-number":["2021\u201002\u2010ZZ\u2010012"]}],"id":[{"id":"10.13039\/100016067","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Exp Pharma Physio"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are life\u2010threatening conditions that involve severe lung inflammation leading to respiratory failure. Tanshinone IIA (TIIA) and Matrine (MAT), two herbal medicinal compounds, have been reported to exhibit several similar pharmacological properties including anti\u2010inflammatory, antioxidant, and anticancer effects. Although previous studies have reported the combined therapeutic efficacy of using two drugs in treating ALI, it remains unknown whether TIIA and MAT have any synergistic effect in alleviating ALI\/ARDS. Therefore, this study investigated whether a combined therapy of TIIA and MAT has protective effects against lipopolysaccharide (LPS)\u2010induced ALI and its mechanism of action using mouse and cell models. The results showed that the TIIA\u2009+\u2009MAT combination ameliorated ALI by reducing edema, tissue injury, and proinflammatory cytokine secretion. This therapy enhanced antioxidant defences, as indicated by upregulated GPX4 and SLC7A11 levels, decreased 4\u2010HNE and ROS levels, and ferroptosis inhibition. Furthermore, TIIA\u2009+\u2009MAT promoted Nrf2 nuclear translocation, leading to increased HO\u20101 expression and an anti\u2010oxidative response. These findings suggest that the combination of TIIA and MAT alleviates LPS\u2010induced ALI by inhibiting ferroptosis via activation of the Nrf2\/HO\u20101 pathway. Thus, the co\u2010administration of TIIA and MAT may be an effective therapeutic strategy for ALI, potentially offering a novel clinical approach to mitigate ferroptosis and inflammation.<\/jats:p>","DOI":"10.1111\/1440-1681.70072","type":"journal-article","created":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T05:02:02Z","timestamp":1759986122000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Combination of Tanshinone\n                    <scp>IIA<\/scp>\n                    and Matrine Alleviates Lipopolysaccharide\u2010Induced Acute Lung Injury by Supressing Ferroptosis via Nrf2\/\n                    <scp>HO<\/scp>\n                    \u20101 Pathway Activation"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-6095-8484","authenticated-orcid":false,"given":"Huanqing","family":"Xiong","sequence":"first","affiliation":[{"name":"Department of Respiration Air Force Medical University Tangdu Hospital  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujuan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Respiration Air Force Medical University Tangdu Hospital  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaying","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Respiration Air Force Medical University Tangdu Hospital  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Respiration Air Force Medical University Tangdu Hospital  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Respiration Air Force Medical University Tangdu Hospital  Xi'an 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,8]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232314959"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.953195"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/crj.13527"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000001598"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.21907"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000001104"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10121956"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2017.11.001"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0b013e31825c7a82"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-8570-8_22"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.1070260512"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/2052-0492-2-10"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/iub.2347"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10020-022-00500-w"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-020-2298-2"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-020-0528-x"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.69141"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-021-04327-7"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s11658-020-00205-0"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-020-01981-4"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2023.109981"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2017.12.001"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2019.03.003"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-018-1016-9"},{"issue":"9","key":"e_1_2_13_26_1","first-page":"4308","article-title":"Matrine 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