{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T19:05:15Z","timestamp":1785351915446,"version":"3.55.0"},"reference-count":25,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T00:00:00Z","timestamp":1758153600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001412","name":"Council of Scientific and Industrial Research, India","doi-asserted-by":"publisher","award":["DUOLP5"],"award-info":[{"award-number":["DUOLP5"]}],"id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Exp Pharma Physio"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Psoriasis is a complex inflammatory autoimmune skin illness that causes epidermal keratinocyte hyperproliferation and dedifferentiation. In a previous study we did in the lab, we found that treating human keratinocytes (HaCaT) with PUVA increased the expression of hsa\u2010miR\u2010718 compared to control. In this study, an imiquimod (IMQ)\u2010induced mouse model and HaCaT were used to look at how overexpressing miR\u2010718 could help treat psoriasis and its causes. To gain more understanding, the in\u00a0vivo study used the JAK1\/3 inhibitor tofacitinib. We observed that miR\u2010718 overexpression leads to the inhibition of JAK\u2013STAT signalling, as evidenced by the reduced expression of STAT1, JAK proteins, and their phosphorylated forms, both in\u00a0vitro and in\u00a0vivo<jats:italic>.<\/jats:italic> Luciferase assay demonstrated the direct inhibition of STAT1 due to miR\u2010718 overexpression. Additionally, in\u00a0vitro experiments showed downregulation of STAT2 and STAT3. Inhibition of basal miR\u2010718 in HaCaT overactivates JAK\u2013STAT signalling proteins. In psoriatic mice, ectopic miR\u2010718 reduces NF\u2010kB, a key mediator of inflammation. IHC shows lower acanthosis and parakeratosis in IMQ\u2010induced psoriatic mice. In the skin of mice that had been miR\u2010718 transfected, there was less VEGF, MMP7 and MMP9. Understanding how miR\u2010718 improves psoriasis not only provides new information but also inspires hope for its potential use as a psoriasis treatment.<\/jats:p>","DOI":"10.1111\/1440-1681.70073","type":"journal-article","created":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T05:17:03Z","timestamp":1758259023000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Overexpression of <scp>miR<\/scp>\u2010718 in Keratinocytes Affects the Psoriatic Inflammation via Targeting <scp>STAT1<\/scp>: In\u00a0Vitro and In\u00a0Vivo Evidence"],"prefix":"10.1111","volume":"52","author":[{"given":"Himani","family":"Rani","sequence":"first","affiliation":[{"name":"CSIR\u2010Institute of Genomics and Integrative Biology (IGIB)  Delhi India"},{"name":"Academy of Scientific &amp; Innovative Research (AcSIR)  Ghaziabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6986-8372","authenticated-orcid":false,"given":"Neeru","family":"Saini","sequence":"additional","affiliation":[{"name":"CSIR\u2010Institute of Genomics and Integrative Biology (IGIB)  Delhi India"},{"name":"Academy of Scientific &amp; 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