{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T12:21:01Z","timestamp":1791807661072,"version":"4.3.4"},"reference-count":32,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T00:00:00Z","timestamp":1761436800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Exp Pharma Physio"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>In this study, we found that PDZK1, a scaffold protein, interacts with the \u03b2\u2082\u2010adrenergic receptor (ADRB2) through its PDZ domains, stabilising ADRB2 by inhibiting its ubiquitination and proteasomal degradation. This study explored the PDZK1\u2013ADRB2 interaction and its role in hypertension\u2010induced vascular remodelling. Using PDZK1 knockout mice infused with angiotensin II, we found that PDZK1 deficiency further exacerbates angiotensin II\u2010induced hypertension, vascular dysfunction, and vascular remodelling. Mechanistically, PDZK1 stabilises ADRB2 protein by preventing its ubiquitination and proteasomal degradation, thereby maintaining ADRB2\u2010mediated vasodilation. Additionally, PDZK1 prevents ADRB2 internalisation and its interaction with \u03b2\u2010arrestin, thereby inhibiting \u03b2\u2010arrestin\u2013mediated ERK activation and suppressing vascular smooth muscle cell (VSMC) phenotypic switching. This mechanism contributes to vascular protection under hypertensive conditions. Targeting the PDZK1\/ADRB2 interaction may provide a novel therapeutic strategy for hypertension\u2010related vascular complications.<\/jats:p>","DOI":"10.1111\/1440-1681.70085","type":"journal-article","created":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T03:26:09Z","timestamp":1761535569000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["<scp>PDZK1<\/scp>\n                    Regulates the Stability and Function of\n                    <scp>ADRB2<\/scp>\n                    to Prevent Vascular Remodelling in Hypertension"],"prefix":"10.1111","volume":"52","author":[{"given":"Haoran","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Cardiology The First Affiliated Hospital of Harbin Medical University  Harbin China"},{"name":"Heilongjiang Province Key Laboratory of Cardiovascular Disease Sound Light Electromagnetic Diagnosis and Treatment The First Affiliated Hospital of Harbin 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