{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T05:13:11Z","timestamp":1764220391548,"version":"3.46.0"},"reference-count":34,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T00:00:00Z","timestamp":1762473600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Exp Pharma Physio"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Venous thromboembolism (VTE) is a complication of head and neck cancer (HNC). However, the effectiveness of routine anticoagulation as a preventive measure and its impact on patient outcomes is unclear. The purpose of this study was to evaluate the association between long\u2010term systemic anticoagulation and in\u2010hospital outcomes of patients with HNC. Data of patients \u2265\u200920\u2009years old with HNC treated from 2005 to 2018 were extracted from the US Nationwide Inpatient Sample (NIS) database. Associations between long\u2010term systemic anticoagulation and in\u2010hospital outcomes were assessed by the univariate and multivariable regression analyses. The study included 20\u2009312 patients with a mean age of 63\u2009years, and 72% were males. Among them, 5078 (25.0%) were on long\u2010term systemic anticoagulation. After adjustment, the multivariable analysis indicated long\u2010term systemic anticoagulation was significantly associated with decreased odds for in\u2010hospital mortality (adjusted odds ratio [aOR]\u2009=\u20090.64, 95% confidence interval [CI]: 0.54\u20130.76,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), overall life\u2010threatening events (aOR\u2009=\u20090.84, 95% CI: 0.78\u20130.92,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), acute myocardial infarction (aOR\u2009=\u20090.76, 95% CI: 0.59\u20130.97,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.026), sepsis (aOR\u2009=\u20090.80, 95% CI: 0.71\u20130.90,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) and acute kidney injury (aOR\u2009=\u20090.86, 95% CI: 0.76\u20130.97,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.015). Long\u2010term systemic anticoagulation was significantly associated with elevated overall bleeding risk (aOR\u2009=\u20091.34, 95% CI: 1.17\u20131.54,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) but not intracerebral haemorrhage (ICH) (aOR\u2009=\u20091.65, 95% CI: 0.90\u20133.04,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.107). In conclusion, in patients with HNC, long\u2010term anticoagulation is associated with better in\u2010hospital outcomes, and does not increase the risk of ICH; however, there is an increased risk of overall bleeding.\n                  <\/jats:p>","DOI":"10.1111\/1440-1681.70087","type":"journal-article","created":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T23:54:11Z","timestamp":1762559651000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Long\u2010Term Anticoagulation and Outcomes of Head and Neck Cancer: Analysis of the\n                    <scp>US<\/scp>\n                    Nationwide Inpatient Sample"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3741-9633","authenticated-orcid":false,"given":"Chun\u2010Feng","family":"Wu","sequence":"first","affiliation":[{"name":"Division of Hematology and Oncology, Department of Internal Medicine Keelung Chang Gung Memorial Hospital  Keelung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4662-1235","authenticated-orcid":false,"given":"Hang Huong","family":"Ling","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, Department of Internal Medicine Keelung Chang Gung Memorial Hospital  Keelung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1935-527X","authenticated-orcid":false,"given":"Yun\u2010Cong","family":"Zheng","sequence":"additional","affiliation":[{"name":"School of Medicine, College of Medicine Chang Gung University  Taoyuan Taiwan"},{"name":"Department of Neurosurgery Keelung Chang Gung Memorial Hospital  Keelung Taiwan"},{"name":"Department of Biomedical Engineering National Taiwan University  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5337-5960","authenticated-orcid":false,"given":"Po\u2010Hsu","family":"Su","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, Department of Internal Medicine Keelung Chang Gung Memorial Hospital  Keelung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsuan\u2010Jen","family":"Shih","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, Department of Internal Medicine Linkou Chang Gung Memorial Hospital  Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Che\u2010Wei","family":"Ou","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, Department of Internal Medicine Linkou Chang Gung Memorial Hospital  Taoyuan Taiwan"},{"name":"Division of Hematology and Oncology, Department of Internal Medicine New Taipei Municipal Tucheng Hospital  New Taipei City Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shih\u2010Ming","family":"Chen","sequence":"additional","affiliation":[{"name":"Bachelor Program in Health Care and Social Work for Indigenous Students Providence University  Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1760-2719","authenticated-orcid":false,"given":"Yu\u2010Cheng","family":"Chang","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, Department of Internal Medicine MacKay Memorial Hospital  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1114-8268","authenticated-orcid":false,"given":"Yen\u2010Min","family":"Huang","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, Department of Internal Medicine Keelung Chang Gung Memorial Hospital  Keelung Taiwan"},{"name":"School of Medicine, College of Medicine Chang Gung University  Taoyuan Taiwan"},{"name":"Hemophilia and Thrombosis Treatment Center Keelung Chang Gung Memorial Hospital  Keelung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,7]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-020-00224-3"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-020-01031-z"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coms.2018.06.001"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.14740\/wjon1104w"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom11091293"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13112609"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminoncol.2014.09.018"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-023-08112-8"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-3848(14)50007-2"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2015.08.006"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/micr.31029"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.3904\/kjim.2021.309"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2013.4911"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-0656"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14030703"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/onco.13698"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020003238"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.21053\/ceo.2015.01781"},{"key":"e_1_2_13_21_1","unstructured":"(HCUP) 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