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Peroxiredoxin 6 (Prdx6), an antioxidant enzyme, plays a crucial role in maintaining ROS homeostasis by degrading hydroperoxides; however, its role in CDDP\u2010induced acute kidney injury (CIAKI) remains unclear. In this study, a CIAKI model was established using CDDP treatment in\u00a0vivo (C57BL\/6 mice) and in\u00a0vitro (PTECs) with or without Prdx6 overexpression (Prdx6 OE). CDDP treatment significantly increased ROS levels, while Prdx6 OE attenuated oxidative stress, apoptosis and renal tubular damage. Furthermore, we found that Prdx6 expression was regulated by Nuclear factor erythroid 2\u2010related factor 2 (Nrf2), suggesting a mechanistic link between Nrf2 and Prdx6 in CIAKI. These findings indicate that Prdx6 plays a protective role in CDDP\u2010induced nephrotoxicity by modulating oxidative stress and apoptosis, and highlight its potential as a therapeutic target.<\/jats:p>","DOI":"10.1111\/1440-1681.70093","type":"journal-article","created":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T05:36:28Z","timestamp":1763703388000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploring the Protective Role and Regulation of Prdx6 in Cisplatin\u2010Induced\n                    <scp>AKI<\/scp>"],"prefix":"10.1111","volume":"53","author":[{"given":"Xianzhe","family":"Li","sequence":"first","affiliation":[{"name":"Department of Nephrology, Zhongshan Hospital Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinbo","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Zhongshan Hospital Fudan University  Shanghai China"},{"name":"Shanghai Medical Center of Kidney Disease  Shanghai China"},{"name":"Shanghai Key Laboratory of Kidney and Blood Purification  Shanghai China"},{"name":"Hemodialysis Quality Control Center of Shanghai  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shi","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Zhongshan Hospital Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaqiong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Zhongshan Hospital Fudan University  Shanghai China"},{"name":"Shanghai Medical Center of Kidney Disease  Shanghai China"},{"name":"Shanghai Key Laboratory of Kidney and Blood Purification  Shanghai China"},{"name":"Hemodialysis Quality Control Center of Shanghai  Shanghai China"},{"name":"Kidney and Dialysis Institute of Shanghai  Shanghai 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