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The overall 5\u2010year survival rate of PaCa is merely 2%\u20139%. Bharangin (BG), a diterpenoid quinonemethide known for its anti\u2010cancer activities, was investigated in a preclinical PaCa model. A dose\u2010 and time\u2010dependent suppression in the viability of PaCa cells was observed by BG. The diterpenoid suppressed the level of tumorigenic proteins in PaCa cells. As evident from phosphatidylserine externalisation, acridine orange (AO)\/propidium iodide (PI) staining, cell cycle analysis and DNA laddering, BG was found to induce apoptosis in PaCa cells. An accumulation in the sub\u2010G1 population was observed by BG. The diterpenoid induced depolarization in the mitochondrial membrane potential and enhanced the PaCa cells' sensitivity to gemcitabine (GEM). The cancer\u2010associated lncRNAs were also modulated by both BG and GEM in PaCa cells. BG also suppressed the p65 nuclear translocation induced by TNF\u2010\u03b1 in PaCa cells. Overall, BG exhibits activities in PaCa cells. The suppression of NF\u2010\u03baB activation and the modulation of lncRNAs expression may provide a basis for further exploration of BG as a therapeutic agent in PaCa.<\/jats:p>","DOI":"10.1111\/1440-1681.70097","type":"journal-article","created":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T00:40:34Z","timestamp":1765240834000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bharangin, A Diterpenoid, Enhances the Sensitivity of Pancreatic Cancer Cells to Gemcitabine Through Involvement of Long Non\u2010Coding RNAs and Nuclear Factor\u2010\u03baB"],"prefix":"10.1111","volume":"53","author":[{"given":"Nikee","family":"Awasthee","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Institute of Science Banaras Hindu University  Varanasi Uttar Pradesh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anusmita","family":"Shekher","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Institute of Medical Sciences Banaras Hindu University  Varanasi Uttar Pradesh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ankit","family":"Srivastava","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Institute of Science Banaras Hindu University  Varanasi Uttar Pradesh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Subash Chandra","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Institute of Science Banaras Hindu University  Varanasi Uttar Pradesh India"},{"name":"Department of Biochemistry All India Institute of Medical Sciences  Guwahati Assam India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,8]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2011.05.011"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14102417"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21763"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12262-015-1365-x"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/17246008070221s410"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6904-5-3"},{"key":"e_1_2_11_8_1","first-page":"97","volume-title":"Proceedings of IUPAC 11th International Symposium of Chemistry of Natural Products","author":"Sankaram A.","year":"1978"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(00)80066-0"},{"issue":"1","key":"e_1_2_11_10_1","first-page":"68","article-title":"A Novel RP\u2010HPLC Method for the Determination of Bharangin in Ghantu Bharangi Crude Extracts","volume":"22","author":"Sathish T.","year":"2009","journal-title":"Pakistan Journal of Pharmaceutical Sciences"},{"key":"e_1_2_11_11_1","first-page":"39","article-title":"Pharmacognosy of a Local Market Sample of Bharangin: Pygmacopremna Herbaceae","volume":"38","author":"Nayar R. 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