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Our study aimed to demonstrate the mechanism underlying olanzapine\u2010induced insulin resistance. In this study, we first analysed the data of 120 schizophrenia patients who had been taking olanzapine for at least 3\u2009months. Eventually, it was found that an increase in circulating tumour necrosis factor\u2010\u03b1 (TNF\u2010\u03b1,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). Subsequently, we verified this finding in a rat model. We detected the expression levels of the target genes fatty acid binding protein 4 (FABP4) and the palmitoyltransferase\n                    <jats:italic>Dhhc7<\/jats:italic>\n                    in both rats and three\u2009T3\u2010L1 adipocytes by using Western blotting and polymerase chain reaction (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). Exposure to olanzapine increased the expression of FABP4 while decreasing the expression of\n                    <jats:italic>Dhhc7<\/jats:italic>\n                    . Additionally, we demonstrated that it may affect metabolism by inhibiting glucose transporter 4 (GLUT4) membrane transport. Finally, we improved olanzapine\u2010induced insulin resistance by injecting FABP4 adenovirus and elucidating its underlying mechanism. In summary, our study demonstrated that long\u2010term exposure to olanzapine increases circulating plasma levels of TNF\u2010\u03b1, thus leading to increased expression of FABP4 protein in white adipose tissue and subsequently inhibiting\n                    <jats:italic>Dhhc7<\/jats:italic>\n                    expression, which correspondingly leads to reduced membrane translocation of GLUT4 and consequent insulin resistance. In conclusion, this study elucidated the signalling pathway through which olanzapine inhibits GLUT4 membrane transport via the TNF\u2010\u03b1\/FABP4\/\n                    <jats:italic>Dhhc7<\/jats:italic>\n                    axis, thus ultimately leading to insulin resistance.\n                  <\/jats:p>","DOI":"10.1111\/1440-1681.70104","type":"journal-article","created":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T04:32:06Z","timestamp":1771216326000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The\n                    <scp>TNF<\/scp>\n                    \u2010\u03b1\u2013\n                    <scp>FABP4<\/scp>\n                    \u2013Dhhc7 Axis Mediates Olanzapine\u2010Induced Insulin Resistance in Rats and Humans"],"prefix":"10.1111","volume":"53","author":[{"given":"Jing","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Union Hospital, Tongji Medical 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