{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T04:21:11Z","timestamp":1773807671188,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,2,22]],"date-time":"2026-02-22T00:00:00Z","timestamp":1771718400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,22]],"date-time":"2026-02-22T00:00:00Z","timestamp":1771718400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100014421","name":"EA Pharma Co., Ltd.","doi-asserted-by":"publisher","award":["AM51EA Pharma"],"award-info":[{"award-number":["AM51EA Pharma"]}],"id":[{"id":"10.13039\/100014421","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Exp Pharma Physio"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Lean metabolic dysfunction\u2010associated steatohepatitis (MASH) is increasingly recognised in non\u2010obese individuals and is associated with cardiovascular complications, including arrhythmias. Although sympathetic activation and inflammation have been implicated in disease progression, their mechanistic roles in cardiac fibrosis and arrhythmogenesis in lean MASH remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the contribution of sympathetic nerve activation to myocardial fibrosis and arrhythmia in a lean MASH mouse model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p>Male C57BL\/6J mice were fed a high\u2010fat\/high\u2010cholesterol diet (STHD\u201001) with or without ethanol for 12\u2009weeks. Hepatic and cardiac changes were evaluated by histology, immunohistochemistry, reverse transcription\u2013polymerase chain reaction, and plasma biochemistry. Arrhythmias were recorded by electrocardiogram telemetry. Despite reduced body weight, mice receiving STHD\u201001 plus ethanol developed marked hepatic and cardiac inflammation and fibrosis. Sympathetic activation, indicated by tyrosine hydroxylase co\u2010localization with cluster of differentiation 68\u2010positive macrophages and with \u03b1\u2010smooth muscle actin\u2013positive fibroblast\u2010like stromal cells, was associated with increased expression of tumour necrosis factor\u2010\u03b1 and transforming growth factor\u2010\u03b21, respectively. These mice exhibited a significantly higher incidence of lethal arrhythmias. Expression of inflammatory and fibrotic genes showed moderate to strong correlations between the liver and heart.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Sympathetic nerve\u2013associated activation of macrophages and fibroblast\u2010like stromal cells is linked to myocardial fibrosis and increased arrhythmia susceptibility in lean MASH. Even modest ethanol intake appears to accelerate disease progression and heighten arrhythmia risk when combined with a high\u2010fat\/high\u2010cholesterol diet. These findings suggest that targeting sympathetic activation and inflammation may represent a potential therapeutic strategy for cardiovascular prevention in lean MASH.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1440-1681.70111","type":"journal-article","created":{"date-parts":[[2026,2,22]],"date-time":"2026-02-22T23:50:38Z","timestamp":1771804238000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sympathetic Nerve Activation Drives Cardiac Fibrosis and Arrhythmia in Lean Metabolic Dysfunction\u2010Associated Steatohepatitis Mice Concurrently Exposed to Ethanol and a High\u2010Fat\/High\u2010Cholesterol Diet"],"prefix":"10.1111","volume":"53","author":[{"given":"Jinyao","family":"Liu","sequence":"first","affiliation":[{"name":"Student Medical Academia Investigation Lab Yamaguchi University Graduate School of Medicine  Ube 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