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The role of HSPB7 in Mfs\u2010related TAA remains poorly understood. By integrating multi\u2010omics analysis with hiPSC\u2010derived VSMCs from patients with Mfs, we elucidated the molecular landscape of Mfs\u2010associated TAA. Analysis revealed immune cell infiltration, a reduced proportion of VSMCs, and altered intercellular communication. Pathway analyses indicated changes in cell adhesion, extracellular matrix (ECM) remodelling, and immune signalling, with downregulated metabolic pathways. Findings suggest structural, immune, and metabolic imbalances in Mfs\u2010TAA pathogenesis. Downregulation of HSPB7 was associated with altered proliferation, migration, and metabolic activity. Overexpression of HSPB7 in patient\u2010specific hiPSC\u2010derived VSMCs attenuated these pathological features and promoted a more contractile phenotype. These findings suggest that HSPB7 may be involved in the regulation of VSMCs' phenotypic modulation in Mfs\u2010TAA and provide mechanistic insight into disease\u2010associated cellular alterations.<\/jats:p>","DOI":"10.1111\/1440-1681.70128","type":"journal-article","created":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T01:14:27Z","timestamp":1779930867000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>HSPB7<\/scp>\n                    Deficiency Drives Aortic Aneurysm Progression in Marfan Syndrome Through Vascular Smooth Muscle Cell Phenotypic Switching"],"prefix":"10.1111","volume":"53","author":[{"given":"Zining","family":"An","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Surgery The First Affiliated Hospital of Nanjing Medical University  Nanjing 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