{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:46:37Z","timestamp":1790696797696,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:00:00Z","timestamp":1778544000000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270321"],"award-info":[{"award-number":["82270321"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170415"],"award-info":[{"award-number":["82170415"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370411"],"award-info":[{"award-number":["82370411"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Exp Pharma Physio"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Hypertension promotes cardiac fibrosis and ultimately leads to heart failure. Piezo1, a new mechanically sensitive cation channel, can transduce mechanical stress into biochemical signals that are necessary for cellular physiological and pathological functions. Although some studies have shown that Piezo1 is involved in the occurrence of cardiovascular disease, whether Piezo1 participates in hypertension\u2010induced cardiac fibrosis, and the detailed molecular mechanisms are still unclear. Experiments were performed on cardiac tissue from spontaneously hypertensive rats (SHRs) and angiotensin II (Ang II)\u2010treated mice. Rat cardiac fibroblasts (RCFs) were exposed to high hydrostatic pressure (HHP, 120 or 180\u2009mmHg) using a self\u2010developed device. We found that Piezo1 expression and \u03b2\u2010catenin activation were markedly elevated in the cardiac tissue of hypertensive animals and in HHP\u2010treated RCFs, accompanied by elevated expression of fibrosis factors, including TGF\u2010\u03b21, collagen I and collagen III. Furthermore, the inhibition or knockdown of Piezo1 (GsMTx4 and siRNA) and \u03b2\u2010catenin (XAV939) alleviated TGF\u2010\u03b21, \u03b1\u2010SMA and collagen expression in HHP\u2010induced RCFs. Importantly, inhibition of Piezo1 decreased the concentration of intracellular Ca\n                    <jats:sup>2+<\/jats:sup>\n                    and the nuclear translocation of \u03b2\u2010catenin. Knockdown of Piezo1 in Ang II\u2010treated mice ameliorated hypertension\u2010induced myocardial fibrosis. Overall, Piezo1 channel activation caused by HHP could result in an increased concentration of intracellular Ca\n                    <jats:sup>2+<\/jats:sup>\n                    and subsequently mediate the nuclear translocation of \u03b2\u2010catenin, leading to the synthesis and secretion of collagen by RCFs. This indicates that targeting Piezo1 could be a potential novel approach for treating cardiac fibrosis induced by hypertension.\n                  <\/jats:p>","DOI":"10.1111\/1440-1681.70130","type":"journal-article","created":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T11:33:51Z","timestamp":1778585631000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Piezo1 Knockdown Attenuates Hypertension\u2010Induced Cardiac Fibrosis by Inhibiting Ca\n                    <sup>2+<\/sup>\n                    \/\u03b2\u2010Catenin Signalling Pathway"],"prefix":"10.1111","volume":"53","author":[{"given":"Lu\u2010An","family":"Li","sequence":"first","affiliation":[{"name":"Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital Guangdong Academy of Medical Sciences  Guangzhou Guangdong China"},{"name":"Guangdong Provincial Key Laboratory of Clinical Pharmacology, Research Center of Medical Sciences, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) Southern Medical University  Guangzhou Guangdong China"},{"name":"Guangzhou First People's Hospital, The Second Affiliated Hospital, School of Medicine South China University of Technology  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing\u2010Rui","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, State Key Laboratory of Respiratory Disease, Institute of Pulmonary Diseases, Guangzhou Chest Hospital Guangzhou Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0408-8094","authenticated-orcid":false,"given":"Li\u2010Bo","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Cardiology Fuwai Hospital Chinese Academy of Medical Sciences  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Yang","sequence":"additional","affiliation":[{"name":"Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital Guangdong Academy of Medical Sciences  Guangzhou Guangdong China"},{"name":"Guangdong Provincial Key Laboratory of Clinical Pharmacology, Research Center of Medical Sciences, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) Southern Medical University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui\u2010Yi","family":"Liu","sequence":"additional","affiliation":[{"name":"Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital Guangdong Academy of Medical Sciences  Guangzhou Guangdong China"},{"name":"Guangdong Provincial Key Laboratory of Clinical Pharmacology, Research Center of Medical Sciences, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) Southern Medical University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Li","sequence":"additional","affiliation":[{"name":"Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital Guangdong Academy of Medical Sciences  Guangzhou Guangdong China"},{"name":"Guangdong Provincial Key Laboratory of Clinical Pharmacology, Research Center of Medical Sciences, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) Southern Medical University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng\u2010Zhen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Clinical Pharmacology, Research Center of Medical Sciences, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) Southern Medical University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun\u2010Yu","family":"Deng","sequence":"additional","affiliation":[{"name":"Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital Guangdong Academy of Medical Sciences  Guangzhou Guangdong China"},{"name":"Guangdong Provincial Key Laboratory of Clinical Pharmacology, Research Center of Medical Sciences, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) Southern Medical University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Rao","sequence":"additional","affiliation":[{"name":"Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital Guangdong Academy of Medical Sciences  Guangzhou Guangdong China"},{"name":"Guangdong Provincial Key Laboratory of Clinical Pharmacology, Research Center of Medical Sciences, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) 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